Coronary Microvascular Rarefaction and Myocardial Fibrosis in Heart Failure with Preserved Ejection Fraction

Selma Mohammed, M.B.B.S.

Heart failure with preserved ejection fraction (HFpEF) is common and increasing in prevalence. HFpEF occurs in association with advanced age and cardiovascular, metabolic and pro-inflammatory comorbidities. Characterization of myocardial structural changes in heart failure with preserved ejection fraction (HFpEF) has been hindered by limited availability of human cardiac tissue.

Mayo Clinic researchers, first author Selma Mohammed, M.B.B.S., conducted a study in Circulation to test the hypothesis that cardiac hypertrophy, microvascular rarefaction and myocardial fibrosis are common and related in patients with HFpEF. For the study, they identified HFpEF patients and age-appropriate control patients (non-cardiac death, no HF diagnosis) who underwent autopsy.

According to the results, subjects with HFpEF had heavier hearts, more severe coronary artery disease (CAD), more left ventricular (LV) fibrosis, and lower microvascular density (MVD) than control. Further, myocardial fibrosis increased with decreasing MVD in controls and HFpEF. Heart weight, fibrosis, and MVD were similar in HFpEF patients with versus without CAD.

Based on these results, patients with HFpEF had more cardiac hypertrophy, epicardial CAD, coronary microvascular rarefaction, and myocardial fibrosis than controls. Each of these findings may contribute to the LV diastolic dysfunction and cardiac reserve function impairment characteristic of HFpEF.

Additional Mayo Clinic authors include: Saad Hussain, M.B.B.S., Sultan Mirzoyev, M.D., William Edwards, M.D., Joseph Maleszewski, M.D., and Margaret Redfield, M.D.

Kelley Luedke

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.