PathWays Case Study: October 20
A 57-year-old woman with a history of acute myeloid leukemia presented with lower extremity edema and weight gain one year following hematopoietic stem cell transplantation (HCT). Her laboratory findings indicate normal renal function, hypoalbuminemia, and a 24-hour urine protein of 1271 mg (normal limits = <167 mg/ 24 hour). Serological studies for complements, antineutrophil antibody (ANA), and antineutrophil cytoplasmic antibody (ANCA) were unremarkable. The serum protein electropheresis (SPEP) and urine protein electropheresis (UPEP) are negative for para-proteins.
Osamah (Sam) AL-Badri, M.B., Ch.B.
Resident, Anatomic Pathology
Mariam (Priya) Alexander, M.D.
Consultant, Division of Anatomic Pathology
Assistant Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine