Mayo Clinic Laboratory and Pathology Research Roundup: Jan. 25

By Kelley Luedke • January 25, 2016

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Welcome to the first Research Roundup which provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

Mass Spectrometry: Transitioning from Bench to Bedside to Improve Patient Care

Mass spectrometry is rapidly transitioning from specialized testing to being broadly applied in the clinical laboratory. This shift has improved the practice of laboratory medicine and enabled physicians to provide better patient care. In a recent review published in Clinical Chemistry, Mayo biochemist Paul Jannetto, Ph.D., and a University of California–San Diego clinical chemist discuss the historical evolution and future applications of mass spectrometry in the clinical laboratory.

Featured Abstracts

Using UCH-L1 to Identify Patients with Aggressive Germinal Center Diffuse Large B-Cell Lymphoma

In a new study published in the journal Blood, Mayo Clinic researchers demonstrate that the UCH-L1 enzyme reflects germinal center in lymphoma and is an oncogenic biomarker of aggressive germinal center B-cells.

CD123 Immunostaining Patterns in Systemic Mastocytosis

CD123 represents a potential therapeutic target in systemic mastocytosis given its absent expression on normal/reactive mast cells and aberrant expression on neoplastic mast cells. Mayo Clinic researchers studied 58 systemic mastocytosis patients to define CD123 expression patterns by immunohistochemistry and its clinical significance. The study was published in the journal Leukemia.

Published to PubMed This Week

• Pancreatic Tumor in a Patient With Parathyroid and Pituitary Disease.
  Mayo Clinic Proceedings
• Prognostic Significance of the Histologic Response of Perihilar Cholangiocarcinoma to Preoperative Neoadjuvant Chemoradiation in Liver Explants.
  American Journal of Surgical Pathology
• Hydroxychloroquine serum concentrations and flares of systemic lupus erythematosus: A longitudinal cohort analysis.
  Arthritis Care & Research
• Fifteen-Minute Detection of Streptococcus pyogenes in Throat Swabs by Use of a Commercially Available Point-of-Care PCR Assay.
  Journal of Clinical Microbiology
• Controlled Delivery of Vancomycin via Charged Hydrogels.
  PLOS One
• Relation of Activated Clotting Times During Percutaneous Coronary Intervention to Outcomes.
  American Journal of Cardiology
• Safety and efficacy of different lenalidomide starting doses in patients with relapsed or refractory chronic lymphocytic leukemia: results of an international multicenter double-blinded randomized phase II trial.
  Leukemia & Lymphoma
• Discontinuation of dialysis with eculizumab therapy in a pediatric patient with dense deposit disease.
  Pediatric Nephrology
• Opioid Tapering in Fibromyalgia Patients: Experience from an Interdisciplinary Pain Rehabilitation Program.
  Pain Medicine
• Scleritis Due to Histoplasmosis.
  Cornea
• Sequential imaging of intraneural sciatic nerve endometriosis provides insight into symptoms of cyclical sciatica.
  Acta Neurochirurgica
• Thiamine deficiency in tachypnoeic Cambodian infants.
  Paediatrics and International Child Health
• Will sacubitril-valsartan diminish the clinical utility of B-type natriuretic peptide testing in acute cardiac care?
  European Heart Journal: Acute Cardiovascular Care
• First application of the Automated QUantitative Analysis (AQUA) technique to quantify PTEN protein expression in ovarian cancer: A correlative study of NCIC CTG OV.16.
  Gynecologic Oncology
• Prognostic interaction between ASXL1 and TET2 mutations in chronic myelomonocytic leukemia.
  Blood Cancer Journal
• P/Q- & N-type calcium channel antibodies: Oncological, neurological & serological accompaniments.
  Muscle & Nerve
• Endoscopic Management of Urolithiasis in the Horseshoe Kidney.
  Urology
• Endoscopic and Pathologic Characterization of Papillary Architecture in Struvite Stone Formers.
  Urology
• Osteogenic potential of human adipose-tissue derived mesenchymal stromal cells cultured on 3D-printed porous structured titanium.
  Gene
• Multiple calibrator measurements improve accuracy and stability estimates of automated assays.
  Scandinavian Journal of Clinical and Laboratory Investigation

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.