Mayo Clinic Laboratory and Pathology Research Roundup: Jan. 25

Welcome to the first Research Roundup which provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

Mass Spectrometry: Transitioning from Bench to Bedside to Improve Patient Care

MassSpec2-960x540Mass spectrometry is rapidly transitioning from specialized testing to being broadly applied in the clinical laboratory. This shift has improved the practice of laboratory medicine and enabled physicians to provide better patient care. In a recent review published in Clinical Chemistry, Mayo biochemist Paul Jannetto, Ph.D., and a University of California–San Diego clinical chemist discuss the historical evolution and future applications of mass spectrometry in the clinical laboratory.

Featured Abstracts

Using UCH-L1 to Identify Patients with Aggressive Germinal Center Diffuse Large B-Cell Lymphoma

Original Title: mmills_medicalsupplies0006.tifIn a new study published in the journal Blood, Mayo Clinic researchers demonstrate that the UCH-L1 enzyme reflects germinal center in lymphoma and is an oncogenic biomarker of aggressive germinal center B-cells.

CD123 Immunostaining Patterns in Systemic Mastocytosis

research-laboratory-test-tubes-and-blue-glove-on-researcher-16x9CD123 represents a potential therapeutic target in systemic mastocytosis given its absent expression on normal/reactive mast cells and aberrant expression on neoplastic mast cells. Mayo Clinic researchers studied 58 systemic mastocytosis patients to define CD123 expression patterns by immunohistochemistry and its clinical significance. The study was published in the journal Leukemia.

Published to PubMed This Week

Kelley Luedke (@kschrib)

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.