Mayo Clinic Laboratory and Pathology Research Roundup: March 14

By Kelley Luedke • March 14, 2016

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

Analyzing Renal Complications in Patients with Chronic Lymphocytic Leukemia or Monoclonal B Lymphocytosis

Renal complications in patients with chronic lymphocytic leukemia (CLL) or monoclonal B lymphocytosis (MBL) are relatively common. However, the cause of renal failure in these patients is unclear. To better understand renal insufficiency, Mayo Clinic researchers reported the pathological findings and outcomes of a series of patients with chronic lymphocytic leukemia or monoclonal B lymphocytosis followed at the Mayo Clinic in Rochester, Minnesota, who underwent a kidney biopsy during the course of their disease. The study was published in the Haematologica journal.

Published to PubMed This Week

• Mutant KRas-Induced Mitochondrial Oxidative Stress in Acinar Cells Upregulates EGFR Signaling to Drive Formation of Pancreatic Precancerous Lesions
  Cell Reports
• Understanding Inherited Genetic Risk of Adult Glioma: A Review
  Neuro-Oncology Practice
• P300 Acetyltransferase Regulates Fatty Acid Synthase Expression, Lipid Metabolism and Prostate Cancer Growth
  Oncotarget
• Diagnosing a Kidney Tumor
  Mayo Clinic Proceedings
• Outcome of Whole Exome Sequencing for Diagnostic Odyssey Cases of an Individualized Medicine Clinic: The Mayo Clinic Experience
  Mayo Clinic Proceedings
• Anastomosing Hemangiomas Arising in Unusual Locations: A Clinicopathologic Study of 17 Soft Tissue Cases Showing a Predilection for the Paraspinal Region
  American Journal of Surgical Pathology
• Accumulating Evidence For a Role of TCF7L2 Variants in Bipolar Disorder With Elevated Body Mass Index
  Bipolar Disorders
• Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade
  Journal of Molecular Diagnostics
• Architecture of the Yeast Mitochondrial Iron-Sulfur Cluster Assembly Machinery: The Sub-Complex Formed by the Iron Donor, Yfh1, and the Scaffold, Isu1
  Journal of Biological Chemistry
• Important Update for the Readers of Our Article
  Cardiology
• Laboratory Test Utilization Management: General Principles and Applications in Hematopathology
  Surgical Pathology Clinics
• Prophylactic Plasma Transfusion for Surgical Patients With Abnormal Preoperative Coagulation Tests: A Single-Institution Propensity-Adjusted Cohort Study
  Lancet Haematology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.