Mayo Clinic Laboratory and Pathology Research Roundup: March 28

By Kelley Luedke • March 28, 2016

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

Multiple Calibrator Measurements Improve Accuracy and Stability Estimates of Automated Assays

Calibration curves are used to convert measured signals—such as light, electrical current, fluorescence, or radioactivity—to concentrations of substances in blood samples. Upon establishing calibration curves, automated analyzers are used to calculate the concentrations of hundreds or thousands of subsequent blood specimens from patients. It has been hypothesized that extra care in the establishment of the stored calibration curve can help improve the patient results and that performing multiple calibrator measurements can improve the overall accuracy of an individual assay. In a recent study, Mayo Clinic researchers investigated the effects of combining multiple calibrations on assay accuracy and measurement of calibration stability. The study was published in the Scandinavian Journal of Clinical and Laboratory Investigation.

Published to PubMed This Week

• The Clinicopathologic Characteristics and Outcome of Atypical Anti-Glomerular Basement Membrane Nephritis
  Kidney International
• Manifestations of Complement-Mediated and Immune Complex-Mediated Membranoproliferative Glomerulonephritis: A Comparative Consecutive Series
  Ophthalmology
• BK Polyomavirus Tubulointerstitial Nephritis With Urothelial Hyperplasia in a Kidney Transplant
  American Journal of Kidney Diseases
• Long-term Quality of Life and Functional Outcomes Among Primary and Secondary Artificial Urinary Sphincter Implantations in Men with Stress Urinary Incontinence
  Journal of Urology
• A Patient with Abnormal Kidney Function and a Monoclonal Light Chain in the Urine
  Clinical Journal of the American Society of Nephrology
• Giant Cell Interstitial Pneumonia in Patients Without Hard Metal Exposure: Analysis of 3 Cases and Review of the Literature
  Human Pathology
• The Prognostic Significance of CD45 Expression by Clonal Bone Marrow Plasma Cells in Patients With Newly Diagnosed Multiple Myeloma
  Leukemia Research
• Long-Term Follow-Up of the Virtue Quadratic® Male Sling
  Urology
• Patients With Mosaic Methylation Patterns of the Prader-Willi/Angelman Syndrome Critical Region Exhibit AS-Like Phenotypes With Some PWS Features
  Molecular Cytogenetics
• Management of a Vesicovaginal Fistula Using Holmium Laser Ablation
  International Urogynecology Journal
• False Negative Cell-Free DNA Screening Result in a Newborn with Trisomy 13
  Case Reports in Genetics

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.