Mayo Clinic Laboratory and Pathology Research Roundup: April 4

By Kelley Luedke • April 4, 2016

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

Testing for Vitamin D Toxicity

Vitamin D is essential for the metabolism and stable equilibrium of calcium and phosphate—elements that are necessary for the growth and development of bones and teeth. Vitamin D also aids in the normal functioning of the body’s nervous system. However, in this era of increased supplementation, there is growing evidence that individuals may be at risk of vitamin D toxicity as a result of overdosing. For patients with vitamin D-related disorders, clinicians measure serum concentrations of 25(OH) D, which have been used as a nutritional marker for assessment of optimum vitamin D supplementation. Researchers at Mayo Clinic developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay to effectively measure vitamin D toxicity. The study was published in Clinical Chemistry.

Published to PubMed This Week

• Implementation of Clinical Decision Support Rules to Reduce Repeat Measurement of Serum Ionized Calcium, Serum Magnesium, and N-Terminal Pro-Brain Natriuretic Peptide in Intensive Care Unit Inpatients
  Clinical Chemistry
• A Young Man With Progressive Language Difficulty and Early-Onset Dementia
  JAMA Neurology
• Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial
  JACC: Cardiovascular Imaging
• From Statistical Significance to Clinical Relevance: A Simple Algorithm to Integrate Brain Natriuretic Peptide and the Seattle Heart Failure Model for Risk Stratification in Heart Failure
  Journal of Heart and Lung Transplantation
• Hepatic Adenomas With Synchronous or Metachronous Fibrolamellar Carcinomas: Both Are Characterized by LFABP Loss
  Modern Pathology
• Temporal IgG Subtype Changes in Recurrent Idiopathic Membranous Nephropathy
  American Journal of Transplantation
• Stones: The Dark Side of Stone Disease - Stones Do Still Kill
  Nature Reviews Urology
• Antimicrobial-loaded Bone Cement Does Not Negatively Influence Sonicate Fluid Culture Positivity for the Diagnosis of Prosthetic Joint Infection
  Journal of Clinical Microbiology
• Repetitive Exercise Dystonia: A Difficult to Treat Hazard of Runner and Non-Runner Athletes
  Parkinsonism & Related Disorders
• Coprophagia in Neurologic Disorders
  Journal of Neurology
• Adenoid Cystic Carcinoma Metastatic to the Pituitary: A Case Report and Discussion of Potential Diagnostic Value of Magnetic Resonance Elastography in Pituitary Tumors
  World Neurosurgery
• Rituximab in a Patient With Splenic Marginal Zone Lymphoma and Acquired Angioedema
  Annals of Allergy, Asthma & Immunology
• An Association of Hippocampal Malformations and Sudden Death? We Need More Data
  Forensic Science, Medicine, and Pathology
• High-Grade Transformation of Acinic Cell Carcinoma: An Inadequately Treated Entity?
  Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology
• Transient Monosomy 7 in a Chronic Myelogenous Leukemia Patient During Nilotinib Therapy: A Case Report
  Clinical Case Reports

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.