Mayo Clinic Laboratory and Pathology Research Roundup: April 4
The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.
Featured Study of the Week
Testing for Vitamin D Toxicity
Vitamin D is essential for the metabolism and stable equilibrium of calcium and phosphate—elements that are necessary for the growth and development of bones and teeth. Vitamin D also aids in the normal functioning of the body’s nervous system. However, in this era of increased supplementation, there is growing evidence that individuals may be at risk of vitamin D toxicity as a result of overdosing. For patients with vitamin D-related disorders, clinicians measure serum concentrations of 25(OH) D, which have been used as a nutritional marker for assessment of optimum vitamin D supplementation. Researchers at Mayo Clinic developed a liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay to effectively measure vitamin D toxicity. The study was published in Clinical Chemistry.
Published to PubMed This Week
- Implementation of Clinical Decision Support Rules to Reduce Repeat Measurement of Serum Ionized Calcium, Serum Magnesium, and N-Terminal Pro-Brain Natriuretic Peptide in Intensive Care Unit Inpatients
Clinical Chemistry - A Young Man With Progressive Language Difficulty and Early-Onset Dementia
JAMA Neurology - Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial
JACC: Cardiovascular Imaging - From Statistical Significance to Clinical Relevance: A Simple Algorithm to Integrate Brain Natriuretic Peptide and the Seattle Heart Failure Model for Risk Stratification in Heart Failure
Journal of Heart and Lung Transplantation - Hepatic Adenomas With Synchronous or Metachronous Fibrolamellar Carcinomas: Both Are Characterized by LFABP Loss
Modern Pathology - Temporal IgG Subtype Changes in Recurrent Idiopathic Membranous Nephropathy
American Journal of Transplantation - Stones: The Dark Side of Stone Disease - Stones Do Still Kill
Nature Reviews Urology - Antimicrobial-loaded Bone Cement Does Not Negatively Influence Sonicate Fluid Culture Positivity for the Diagnosis of Prosthetic Joint Infection
Journal of Clinical Microbiology - Repetitive Exercise Dystonia: A Difficult to Treat Hazard of Runner and Non-Runner Athletes
Parkinsonism & Related Disorders - Coprophagia in Neurologic Disorders
Journal of Neurology - Adenoid Cystic Carcinoma Metastatic to the Pituitary: A Case Report and Discussion of Potential Diagnostic Value of Magnetic Resonance Elastography in Pituitary Tumors
World Neurosurgery - Rituximab in a Patient With Splenic Marginal Zone Lymphoma and Acquired Angioedema
Annals of Allergy, Asthma & Immunology - An Association of Hippocampal Malformations and Sudden Death? We Need More Data
Forensic Science, Medicine, and Pathology - High-Grade Transformation of Acinic Cell Carcinoma: An Inadequately Treated Entity?
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology - Transient Monosomy 7 in a Chronic Myelogenous Leukemia Patient During Nilotinib Therapy: A Case Report
Clinical Case Reports