Mayo Clinic Laboratory and Pathology Research Roundup: April 11
The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.
Featured Study of the Week
Quality Improvement Initiative to Prevent Unnecessary Blood Transfusions and Reduce Multiple-Donor Exposure among Premature Infants
Premature infants often develop anemia as a result of hemorrhage, immature hematopoiesis, and frequent blood sampling. As a result, these infants frequently receive packed red blood cell (PRBC) transfusions, with up to 80% receiving multiple transfusions. Tragically, a number of morbidities have been associated with PRBC transfusions in this population—due to transfusion reactions and other complications unique to neonates. In an initiative to reduce the risk of unnecessary PRBC transfusions, leadership at Mayo Clinic’s Newborn Intensive Care Unit has developed and implemented an evidence-based PRBC transfusion guideline for extremely low-birth-weight infants. The article was published in Advances in Neonatal Care.
First Report of MYD88L265P Somatic Mutation in IgM-Associated Light Chain Amyloidosis
A mutation in myeloid differentiation factor gene, MYD88, leading to constitutive activation of the nuclear factor (NF)-κB pathway was shown to be oncogenically active in some patients with activated B-cell (ABC) type-diffuse large B-cell lymphoma (DLBCL). Mayo Clinic researchers conducted a study to detect the frequency of activating MYD88 mutation in IgM amyloidosis cases and identify clinicopathologic correlations. The study was published in Blood Journal.
Published to PubMed This Week
- Incorporation of Tissue-Based Genomic Biomarkers Into Localized Prostate Cancer Clinics
- Molecular Classification of Cancer With the 92-Gene Assay in Cytology and Limited Tissue Samples
- Man With Fever and Severe Diarrhea
Mayo Clinic Proceedings
- Association of Ovary-Sparing Hysterectomy With Ovarian Reserve
Obstetrics & Gynecology
- Relationship of Blood Monocytes With Chronic Lymphocytic Leukemia Aggressiveness and Outcomes: A Multi-Institutional Study
American Journal of Hematology
- Pre-Treatment Neutrophil-to-Lymphocyte Ratio Predicts Tumor Pathology in Newly Diagnosed Renal Tumors
World Journal of Urology