Mayo Clinic Laboratory and Pathology Research Roundup: April 11

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

Quality Improvement Initiative to Prevent Unnecessary Blood Transfusions and Reduce Multiple-Donor Exposure among Premature Infants

Blood-960x540Premature infants often develop anemia as a result of hemorrhage, immature hematopoiesis, and frequent blood sampling. As a result, these infants frequently receive packed red blood cell (PRBC) transfusions, with up to 80% receiving multiple transfusions. Tragically, a number of morbidities have been associated with PRBC transfusions in this population—due to transfusion reactions and other complications unique to neonates. In an initiative to reduce the risk of unnecessary PRBC transfusions, leadership at Mayo Clinic’s Newborn Intensive Care Unit has developed and implemented an evidence-based PRBC transfusion guideline for extremely low-birth-weight infants. The article was published in Advances in Neonatal Care.

Featured Abstracts

First Report of MYD88L265P Somatic Mutation in IgM-Associated Light Chain Amyloidosis

Original Title: mmills_medicalsupplies0006.tifA mutation in myeloid differentiation factor gene, MYD88, leading to constitutive activation of the nuclear factor (NF)-κB pathway was shown to be oncogenically active in some patients with activated B-cell (ABC) type-diffuse large B-cell lymphoma (DLBCL). Mayo Clinic researchers conducted a study to detect the frequency of activating MYD88 mutation in IgM amyloidosis cases and identify clinicopathologic correlations. The study was published in Blood Journal

Published to PubMed This Week

Kelley Luedke

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.