Mayo Clinic Laboratory and Pathology Research Roundup: April 18

By Kelley Luedke • April 18, 2016

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

Assessing the Value of LMO2 as a Biomarker for T-Lymphoblastic Leukemia/Lymphoma

T-lymphoblastic leukemia/lymphoma (also known as T-cell acute lymphoblastic leukemia or “T‑ALL”) is an aggressive cancer caused by an overproduction of immature T cells. Recent research suggests that the protein LMO2 appears to be a biomarker of transformed T‑precursor cells. In a recent study published in the American Journal of Clinical Pathology, Mayo Clinic researchers tested the specificity of LMO2 for distinction between neoplastic and non-neoplastic T-precursor cells in the thymus and bone marrow.

Published to PubMed This Week

• Activation of P-TEFb by Androgen Receptor-Regulated Enhancer RNAs in Castration-Resistant Prostate Cancer
  Cell Reports
• Clinical and Immunologic Investigations in Patients With Stiff-Person Spectrum Disorder
  JAMA Neurology
• Pancreatic Cyst Epithelial Denudation: a Natural Phenomenon in the Absence of Treatment
  Gastrointestinal Endoscopy
• Morphologic Features of ALK-negative Anaplastic Large Cell Lymphomas With DUSP22 Rearrangements
  American Journal of Surgical Pathology
• Cefepime Susceptible-Dose-Dependent MIC for Enterobacteriaceae: Impact on Reporting and Prescribing
  Antimicrobial Agents and Chemotherapy
• Molecular Correlates of Anemia in Primary Myelofibrosis: A Significant and Independent Association With U2AF1 Mutations
  Blood Cancer Journal
• Survival Trends in Primary Myelodysplastic Syndromes: A Comparative Analysis of 1000 Patients By Year of Diagnosis and Treatment
  Blood Cancer Journal
• Direct Electrical Current Reduces Bacterial and Yeast Biofilm Formation
  International Journal of Bacteriology
• Adenocarcinoma in Situ, Minimally Invasive Adenocarcinoma, and Invasive Pulmonary Adenocarcinoma-Analysis of Interobserver Agreement, Survival, Radiographic Characteristics, and Gross Pathology in 296 Nodules
  Human Pathology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.