Mayo Clinic Laboratory and Pathology Research Roundup: April 25

By Kelley Luedke • April 25, 2016

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

Consortium Study of Dohner Hierarchical Classification of Chronic Lymphocytic Leukemia Reveals Improved Survival

Back in 2000, a German study guided by Hartmut Dohner, M.D., established the prognostic association of chromosome abnormalities identified by fluorescence in situ hybridization (FISH) analysis in patients with chronic lymphocytic leukemia (CLL). Since then, the “Dohner hierarchical classification” has been the gold standard by which clinicians in both academic and community settings treat and counsel their CLL patients. Now, more than 15 years later, a multi-institutional study, led by Mayo Clinic, revisited the Dohner hierarchy. Why? To learn if the original prognostic association still holds true. According to the new study, published in the British Journal of Haematology, this FISH hierarchy has indeed stood the test of time. Further, overall survival is now significantly longer in CLL patients—at least partly due to improved therapeutic options.

Published to PubMed This Week

• BLM Promotes the Activation of Fanconi Anemia Signaling Pathway
  Oncotarget
• Sex-Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction
  Journal of the American Heart Association
• Genes Associated With Histopathologic Features of Triple Negative Breast Tumors Predict Molecular Subtypes
  Breast Cancer Research and Treatment
• ROBUST: Lenalidomide-R-CHOP Versus Placebo-R-CHOP in Previously Untreated ABC-Type Diffuse Large B-Cell Lymphoma
  Future Oncology
• Determining the Frequency of Pathogenic Germline Variants From Exome Sequencing in Patients With Castrate-Resistant Prostate Cancer
  BMJ Open
• Hypothalamic Hamartoma With Neurofibrillary Tangles
  Neuropathology
• Total Red Blood Cell Transfusions for Chronic Hemodialysis Patients in a Single Center, 2009-2013
  Nephron

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.