Mayo Clinic Laboratory and Pathology Research Roundup: April 25
The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.
Featured Study of the Week
Consortium Study of Dohner Hierarchical Classification of Chronic Lymphocytic Leukemia Reveals Improved Survival
Back in 2000, a German study guided by Hartmut Dohner, M.D., established the prognostic association of chromosome abnormalities identified by fluorescence in situ hybridization (FISH) analysis in patients with chronic lymphocytic leukemia (CLL). Since then, the “Dohner hierarchical classification” has been the gold standard by which clinicians in both academic and community settings treat and counsel their CLL patients. Now, more than 15 years later, a multi-institutional study, led by Mayo Clinic, revisited the Dohner hierarchy. Why? To learn if the original prognostic association still holds true. According to the new study, published in the British Journal of Haematology, this FISH hierarchy has indeed stood the test of time. Further, overall survival is now significantly longer in CLL patients—at least partly due to improved therapeutic options.
Published to PubMed This Week
- BLM Promotes the Activation of Fanconi Anemia Signaling Pathway
- Sex-Specific Genetic Variants are Associated With Coronary Endothelial Dysfunction
Journal of the American Heart Association
- Genes Associated With Histopathologic Features of Triple Negative Breast Tumors Predict Molecular Subtypes
Breast Cancer Research and Treatment
- ROBUST: Lenalidomide-R-CHOP Versus Placebo-R-CHOP in Previously Untreated ABC-Type Diffuse Large B-Cell Lymphoma
- Determining the Frequency of Pathogenic Germline Variants From Exome Sequencing in Patients With Castrate-Resistant Prostate Cancer
- Hypothalamic Hamartoma With Neurofibrillary Tangles
- Total Red Blood Cell Transfusions for Chronic Hemodialysis Patients in a Single Center, 2009-2013