Mayo Clinic Laboratory and Pathology Research Roundup: May 9

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

The Challenge of Celiac Disease Diagnosis

GI-Infections-960x540Celiac disease is an autoimmune disorder where the ingestion of gluten leads to damage in the small intestine. According to the Celiac Disease Foundation, celiac disease is estimated to affect 1 in 100 people worldwide, and approximately 2.5 million Americans are undiagnosed and are at risk for long-term health complications. Establishing an accurate diagnosis is critical for improved quality of life and prevention of associated side effects. Unfortunately, celiac disease is a challenge to diagnose. Mayo Clinic researchers conducted a thorough review to examine diagnostic testing strategies for celiac disease, focusing on published guidelines, for the evaluation of patients with suspected celiac disease. The review was published in the Expert Review of Clinical Immunology.

Featured Abstracts

Predictors of Survival in WHO-Defined Hypereosinophilic Syndrome and Idiopathic Hypereosinophilia and the Role of Next-Generation Sequencing

The natural history of primary eosinophilic disorders remains poorly defined, given the underlying disease heterogeneity. Patients who do not fit into the WHO (World Health Organization) classification of primary eosinophilias are classified as idiopathic hypereosinophilia (IHE), including idiopathic hypereosinophilic syndrome (HES). Mayo Clinic researchers conducted a study to identify predictors of inferior overall survival in HES/IHE patients including relevant molecular parameters using next-generation sequencing. The study was published in Leukemia

Published to PubMed This Week

Kelley Luedke (@kschrib)

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.