Mayo Clinic Laboratory and Pathology Research Roundup: May 30

By brentwestra • May 30, 2016

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

Diagnosing Prosthetic Joint Infection by Culturing Periprosthetic Tissue Specimens in Blood Culture Bottles

Prosthetic joint infections are challenging to diagnose because current detection methods are often unreliable. Mayo Clinic researchers conducted a study to compare the sensitivity and specificity of inoculation of periprosthetic tissue specimens into blood culture bottles with standard agar and broth cultures, applying Bayesian latent class modeling in addition to applying the Infectious Diseases Society of America criteria for prosthetic joint infection. The study, published in mBio, compared the sensitivity and specificity of different culture techniques alone and in combination and assessed time to positivity.

Published to PubMed This Week

• Benefit-Risk Evaluation for Diagnostics: A Framework (BED-FRAME)
  Clinical Infectious Diseases
• Suppression of Endogenous Lipogenesis Induces Reversion of the Malignant Phenotype and Normalized Differentiation in Breast Cancer
  Oncotarget
• Alterations of Androgen Receptor-Regulated Enhancer RNAs (eRNAs) Contribute to Enzalutamide Resistance in Castrationresistant Prostate Cancer
  Oncotarget
• Targeted Next Generation Sequencing of Endoscopic Ultrasound Acquired Cytology From Ampullary and Pancreatic adenocarcinoma Has the Potential to Aid Patient Stratification for Optimal Therapy Selection
  Oncotarget
• Imaging Findings of Cerebral Amyloid Angiopathy, Aβ-Related Angiitis (ABRA), and Cerebral Amyloid Angiopathy-Related Inflammation: A Single-Institution 25-Year Experience
  Medicine
• Antitumor Effect of FGFR Inhibitors on a Novel Cholangiocarcinoma Patient Derived Xenograft Mouse Model Endogenously Expressing an FGFR2-CCDC6 Fusion Protein
  Cancer Letters
• Brief Report: S768I Mutation in EGFR in Patients With Lung Cancer
  Journal of Thoracic Oncology
• Risk of Extracolonic Cancers for People with Biallelic and Monoallelic Mutations in MUTYH
  International Journal of Cancer
• Central Nervous System Relapse in Patients with Untreated HER2-Positive Esophageal or Gastroesophageal Junction Adenocarcinoma
  International Journal of Cancer
• SphK1 Inhibitor Potentiates the Anti-Cancer Effect of EGCG on Leukaemia Cells
  British Journal of Haematology
• An Immunocompromised Child with Bloodstream Infection Caused by Two Escherichia coli Strains, One Harboring NDM-5 and the Other Harboring OXA-48-Like Carbapenemase
  Antimicrobial Agents and Chemotherapy
• Differential Antimicrobial Susceptibilities of Granulicatella Adiacens and Abiotrophia Defectiva
  Antimicrobial Agents and Chemotherapy
• A Picture is Worth a Thousand Words: Intraoperative Photography as a Quality Metric for Axillary Dissection
  Annals of Surgical Oncology
• Next-Generation Sequencing in Systemic Mastocytosis: Derivation of a Mutation-Augmented Clinical Prognostic Model for Survival
  American Journal of Hematology
• Characterization of Inner Medullary Collecting Duct Plug Formation Among Idiopathic Calcium Oxalate Stone Formers
  Urology
• Ex Vivo Renal Stone Characterization with Single-Source Dual-Energy Computed Tomography: A Multiparametric Approach
  Academic Radiology
• Idiopathic Granulomatous Mastitis: Imaging Update and Review
  Insights Imaging

brentwestra

Brent Westra is a Marketing Segment Manager at Mayo Clinic Laboratories. He leads marketing strategies for product management and specialty testing along with new media innovations. Brent has worked at Mayo Clinic since 2011.