Mayo Clinic Laboratory and Pathology Research Roundup: June 13

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including a featured article of the week, abstracts, and complete list of published studies and reviews.

Featured Study of the Week

Testing for Herpes Simplex Virus in Low-Volume Cerebrospinal Fluid Samples

HerpesSimplexVirus-960x540Detection of herpes simplex virus types 1 or 2 in cerebrospinal fluid is considered a medical emergency, especially in infants and young children. If untreated, HSV encephalitis can have a mortality rate of 70%. To determine the optimal method for detection of HSV-1/2, Mayo Clinic researchers compared the Mayo Medical Laboratories routine real-time PCR method to three protocols designed to analyze CSF samples. The study was published in the Journal of Clinical Microbiology.

Featured Abstracts

Clinical, Biopsy, and Mass Spectrometry Characteristics of Renal Apolipoprotein A-IV Amyloidosis

Apolipoprotein A-IV associated amyloidosis (AApoAIV amyloidosis) is a rare cause of amyloidosis with only a single reported case. Mayo Clinic researchers described the clinical, biopsy, and mass spectrometry characteristics of 11 cases of renal AApoAIV amyloidosis. Progressive chronic kidney disease was the most common cause for biopsy with proteinuria absent or minimal in all except one. Hematological and serological evaluation was negative in 9 patients, while 2 had a monoclonal gammopathy. The renal biopsy findings were striking and showed large amounts of eosinophilic Congo-red positive amyloid deposits restricted to the renal medulla with sparing of the renal cortex. In 6 cases, peritubular amyloid was noted in addition to the interstitial involvement. Immunofluorescence studies were negative for immunoglobulins. Thus, renal AApoAIV amyloidosis typically presents with progressive chronic kidney disease and histologically exhibits extensive medullary involvement with sparing of the cortex. The diagnosis is best established by mass spectrometry. Hence, a high degree of suspicion and examination of the renal medulla is required to make the diagnosis. The study was published in Kidney International.

Published to PubMed This Week

brentwestra (@brentwestra)


Brent Westra is a Marketing Segment Manager at Mayo Clinic Laboratories. He leads marketing strategies for product management and specialty testing along with new media innovations. Brent has worked at Mayo Clinic since 2011.