PathWays Case Study for July 26

A female patient was admitted due to a short history of lower abdominal pain. Emergent exploratory laparotomy revealed a ruptured left ovarian mass. Grossly, the tumor measured 28 cm in greatest dimension with a cystic and solid-cut surface. Immunohistochemical stains were performed, and the tumor cells were strongly positive for chromogranin A, synaptophysin, CK AE1/AE3, and CK20. Representative H&E images are shown here. A diagnosis of ovarian large cell neuroendocrine carcinoma was made.

H&E 100x
H&E 400x

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Xiaotun Zhang, M.B.
Resident, Anatomic Pathology Residency
Mayo Clinic




Debra A. Bell, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine



April Josselyn is a Marketing Channel Manager at Mayo Clinic Laboratories. She has worked at Mayo Clinic since 2012. Outside of work, April enjoys the outdoors and being "hockey mom" for her two sports-crazed boys.