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PathWays Case Study: Aug. 9

A 57-year-old woman was diagnosed with acute promyelocytic leukemia (APL) involving 40% of her bone marrow confirmed by PML-RARA quantitative PCR. She was started on induction therapy but developed treatment-related long QTc syndrome. Her regimen was reduced, and soon after, a follow-up bone marrow biopsy was performed. The bone marrow aspirate showed no morphologic features of residual acute leukemia but did reveal markedly bizarre erythroid atypia not seen in her earlier bone marrow specimen (see images).

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Justin Juskewitch, M.D., Ph.D.

Justin Juskewitch, M.D., Ph.D.
Resident, Division of Anatomic and Clinical Pathology
Mayo Clinic

 

 

 

 

Min Shi, M.D., Ph.D.

Min Shi, M.D., Ph.D.
Consultant, Division of Hematopathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine

apriljosselyn

apriljosselyn

April Josselyn is a Marketing Channel Manager at Mayo Clinic Laboratories. She has worked at Mayo Clinic since 2012. Outside of work, April enjoys the outdoors and being "hockey mom" for her two sports-crazed boys.