PathWays Case Study: Aug. 16

The patient is a 45-year-old man who presented with renal vein thrombosis requiring urgent anti-coagulation. His serum creatinine was 1.1 mg/dL with an albumin of 3.2 g/dL. No monoclonal proteins were detected on serum protein electrophoresis. Cryoglobulins and cryofibrinogens were negative. C3 was elevated at 181 mg/dL and C4 was normal at 29 mg/dL. ANA and Anti-ds DNA were negative. Quantitative urinalysis shows a total protein of 3665 mg/24 hour.


Immunofluorescence: IgG

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Pingchuan Zhang, B.M.
Resident, Renal Pathology
Mayo Clinic






Mariam (Priya) Alexander, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine



April Josselyn is a Marketing Channel Manager at Mayo Clinic Laboratories. She has worked at Mayo Clinic since 2012. Outside of work, April enjoys the outdoors and being "hockey mom" for her two sports-crazed boys.