Mayo Clinic Laboratory and Pathology Research Roundup: Sept. 26

By brentwestra • September 26, 2016

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Association of B-Type Natriuretic Peptide With Survival in Patients With Degenerative Mitral Regurgitation

Studies suggesting that B-type natriuretic peptide (BNP) may predict outcomes of mitral regurgitation (MR) are plagued by small size, inconsistent etiologies, and lack of accounting for shifting normal BNP ranges with age and sex. Mayo Clinic researchers conducted a study to assess the effect of BNP activation on mortality in a large, multicenter cohort of patients with degenerative MR. The study found that in patients with degenerative MR, BNP ratio is a powerful, independent, and incremental predictor of long-term mortality under medical management. BNP ratio should be incorporated into the routine clinical assessment of patients with degenerative MR. The study was published in the Journal of the American College of Cardiology. 

Published to PubMed This Week

• Montelukast Does not Maintain Symptom Reductions Following Topical Steroid Therapy for Eosinophilic Esophagitis
  Clinical Gastroenterology and Hepatology
• Multidisciplinary Model to Implement Pharmacogenomics at the Point of Care
  Genetics in Medicine
• Incorporating Functional Annotations for Fine-Mapping Causal Variants in a Bayesian Framework Using Summary Statistics
  Genetics
• Common Fragile Sites and Extremely Large are Targets for Human Papillomavirus Integrations and Chromosome Rearrangements in Oropharyngeal Squamous Cell Carcinoma
  Genes Chromosomes Cancer
  
• Germline miRNA DNA Variants and the Risk of Colorectal Cancer by Subtype
  Genes Chromosomes Cancer
• Riedel's Thyroiditis Association with IgG4-Related Disease
  Clinical Endocrinology
• Invasive Ductal Carcinoma With in situ Pattern: How to Avoid This Diagnostic Pitfall?
  American Journal of Translational Research
• Frozen Section Analysis of SLNs in Trunk and Extremity Melanoma Has a High False Negative Rate but Can Spare Some Patients a Second Operation
  Journal of Surgical Oncology
• Detection of High-Risk Human Papillomavirus Infection in Tonsillar Specimens Using 2 Commercially Available Assays
  Diagnostic Microbiology and Infectious Disease
• Risk of Chronic Kidney Disease in Brushite Stone Formers Compared to Idiopathic Calcium Oxalate Stone Formers
  Urology
• Vancomycin-Resistant Enterococcus Colonization and Bloodstream Infection
  Transplant Infectious Disease
• ALK-rearranged Inflammatory Myofibroblastic Tumor of the Placenta, With Observations on Site of Origin
  International Journal of Gynecological Pathology
• Female Urethral Diverticulum: Presentation, Diagnosis, and Predictors of Outcomes After Surgery
  Female Pelvic Medicine & Reconstructive Surgery
  
• Hemodynamic Transesophageal Echocardiography-Guided Venous-Arterial Extracorporeal Membrane Oxygenation Support in a Case of Giant Cell Myocarditis
  Case Reports in Critical Care

brentwestra

Brent Westra is a Marketing Segment Manager at Mayo Clinic Laboratories. He leads marketing strategies for product management and specialty testing along with new media innovations. Brent has worked at Mayo Clinic since 2011.