Mayo Clinic Laboratory and Pathology Research Roundup: Oct. 31
The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Featured Abstracts
Natural History of Wild-Type Transthyretin Cardiac Amyloidosis and Risk Stratification Using a Novel Staging System
Wild-type transthyretin cardiac amyloidosis (ATTRwt) is increasingly recognized as an important cause of heart failure. Mayo Clinic researchers conducted a study to determine the natural history of ATTRwt and the predictors of survival. Multivariate predictors of mortality included age, ejection fraction, pericardial effusion, N-terminal pro-B-type natriuretic peptide, and troponin T. A staging system was developed that used thresholds of troponin T and N-terminal pro-B-type natriuretic peptide. The natural history of ATTRwt is poor. We report a novel cardiac biomarker staging system that enables risk stratification in an era of emerging treatment strategies.The respective 4-year overall survival estimates were 57%, 42%, and 18% for stage I (both values below cutoff), stage II (one above), and stage III (both above), respectively. Stage III patients were at an increased risk of mortality after adjustment for age and sex compared with stage I. Based on the results, the natural history of ATTRwt is poor. Researchers reported a novel cardiac biomarker staging system that enables risk stratification in an era of emerging treatment strategies. The paper was published in the Journal of American College of Cardiology.
Quantitation of Albumin in Urine by Liquid Chromatography Tandem Mass Spectrometry
Urinary excretion of human serum albumin (HSA), a 6.65 kDa monomeric protein, is a sensitive marker of renal damage associated with many diseases including diabetes mellitus. Albumin is synthesized by the liver and functions as a transport protein for fat-soluble hormones and drugs and for maintaining plasma colloid osmotic pressure and pH. Albumin is not filtered at the glomerulus and its presence in the urine at concentration above 30 mg/day is suggestive of glomerular damage. Early diagnosis of microalbuminuria has prognostic value for monitoring disease progression and early clinical management of diabetic nephropathy in prediabetic patients. Current methods for quantitation of urine albumin are based on immunoassays or size exclusion high-performance liquid chromatography coupled with UV detection (SEC-HPLC-UV). Studies have demonstrated discordance between the existing methods. It has been suggested that while immunoassays underestimate albumin in urine, SEC-HPLC-UV method overestimates albumin as it cannot separate co-eluting interferences. Mayo Clinic researchers describe a liquid chromatography tandem mass spectrometry LC-MS/MS candidate reference method for albumin quantitation. The study was published in Methods in Molecular Biology.
Published to PubMed This Week
- Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy
Cancer Research - A Proposal for a Serology-Based Approach to Membranous Nephropathy
Journal of the American Society of Nephrology - In Reply to 'C4 Deposition in Glomerular Disease'
American Journal of Kidney Diseases - Custom Gene Capture and Next-Generation Sequencing to Resolve Discordant ALK Status by FISH and IHC in Lung Adenocarcinoma
Journal of Thoracic Oncology - Radiologic Response to Neoadjuvant Treatment Predicts Histologic Response in Thymic Epithelial Tumors
Journal of Thoracic Oncology - Early Event Status Informs Subsequent Outcome in Newly Diagnosed Follicular Lymphoma
American Journal of Hematology - Outcomes of Patients With Renal Monoclonal Immunoglobulin Deposition Disease
American Journal of Hematology - Clinical-Radiological-Pathological Spectrum of Central Nervous System-Idiopathic Inflammatory Demyelinating Disease in the Elderly
Multiple Sclerosis Journal - Mitochondrial DNA Sequence Data Reveals Association of Haplogroup U With Psychosis in Bipolar Disorder
Journal of Psychiatric Research - MPL Mutations and Palpable Splenomegaly are Independent Risk Factors for Fibrotic Progression in Essential Thrombocythemia
Blood Cancer Journal - Urinary Collecting System Invasion is Associated With Poor Survival in Patients With Clear-Cell Renal Cell Carcinoma
BJU International - Impact of RNA degradation on Fusion Detection by RNA-Seq
BMC Genomics - Examining the Role of Preoperative Positron Emission Tomography/Computerized Tomography (PET/CT) in Combination with Ultrasonography in Discriminating Benign from Malignant Cytologically Indeterminate Thyroid Nodules
Thyroid - Are Patients Willing to Incur Out-of-Pocket Costs for Pharmacogenomic Testing?
Pharmacogenomics Journal - A Genome Wide Association Study Suggests the Association of Muskelin with Early Onset Bipolar Disorder: Implications for a GABAergic Epileptogenic Neurogenesis Model
Journal of Affective Disorders - Effect of Ventricular Arrhythmia Ablation in Patients with Heart Mate II Left Ventricular Assist Devices: An Evaluation of Ablation Therapy
Journal of Cardiovascular Electrophysiology - Correlating Tumor Stiffness with Immunohistochemical Subtypes of Breast Cancers: Prognostic Value of Comb-Push Ultrasound Shear Elastography for Differentiating Luminal Subtypes
PLoS One - Examining the Role of Preoperative Positron Emission Tomography/Computerized Tomography (PET/CT) in Combination with Ultrasonography in Discriminating Benign from Malignant Cytologically Indeterminate Thyroid Nodules
Thyroid - Misconceptions About Malignant Metamorphosis in Myxoma
Annals of Thoracic Surgery - Oncocytic Variant of Malignant Gastrointestinal Neuroectodermal Tumor: A Potential Diagnostic Pitfall
Human Pathology - Pseudolipoblastic Perineurioma: An Unusual Morphological Variant of Perineurioma That May Simulate Liposarcoma
Human Pathology - Malignant Transformation of Polyostotic Fibrous Dysplasia With Aberrant Keratin Expression
Human Pathology - Deletion 5q is Frequent in Myelodysplastic Syndrome (MDS) Patients Diagnosed With Interstitial Lung Diseases (ILD): Mayo Clinic Experience
Leukemia Research - Risk of Chronic Kidney Disease in Brushite Stone Formers Compared With Idiopathic Calcium Oxalate Stone Formers
Annals of Thoracic Surgery - Oncocytic Variant of Malignant Gastrointestinal Neuroectodermal Tumor: A Potential Diagnostic Pitfall
Human Pathology - Pseudolipoblastic Perineurioma: An Unusual Morphological Variant of Perineurioma That May Simulate Liposarcoma
Urology - Female Urethral Diverticulum: Presentation, Diagnosis, and Predictors of Outcomes After Surgery
Female Pelvic Medicine & Reconstructive Surgery - Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytology of Metastatic Renal Cell Carcinoma to the Pancreas: A Multi-Center Experience
Cytojournal - Polyclonal Localized Light Chain Amyloidosis-A Distinct Entity
Clinical Lymphoma Myeloma and Leukemia - Appointment Lead Time Policy Development to Improve Patient Access to Care
Applied Clinical Informatics - Refining the Diagnosis of Type 2 Myocardial Infarction
JAMA Cardiology