Mayo Clinic Laboratory and Pathology Research Roundup: Nov. 7
The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Featured Abstract
Chromoplectic TPM3-ALK Rearrangement in a Patient with Inflammatory Myofibroblastic Tumor

Inflammatory myofibroblastic tumors (IMTs) are rare sarcomas that can occur at any age. Surgical resection is the primary treatment for patients with localized disease; however, these tumors frequently recur. Less commonly, patients with IMTs develop or present with metastatic disease. There is no standard of care for these patients and traditional cytotoxic therapy is largely ineffective. Most IMTs are associated with oncogenic ALK, ROS1 or PDGFRβ fusions and may benefit from targeted therapy. Mayo Clinic researchers conducted a study to understand the genomic abnormalities of a patient who presented for management of metastatic IMT after progression of disease on crizotinib and a significant and durable partial response to the more potent ALK inhibitor ceritinib. In their analysis of the treatment-resistant, residual IMT, researchers identified a complex pattern of genetic rearrangements consistent with chromoplexy. Although it is difficult to know for certain if these chromoplectic rearrangements preceded treatment, their presence suggests that chromoplexy has a role in the oncogenesis of IMTs. Furthermore, this patient's remarkable response suggests that ceritinib should be considered as an option after progression on crizotinib for patients with metastatic or unresectable IMT and ALK mutations. The paper was published in Annals of Onocology.
Published to PubMed This Week
- Individualized Approaches Are Needed for Optimized Blood Cultures
Clinical Infectious Diseases - Safety of Intrathecal Autologous Adipose-Derived Mesenchymal Stromal Cells in Patients with ALS
Neurology - Robust Oncolytic Virotherapy Induces Tumor Lysis Syndrome and Associated Toxicities in the MPC-11 Plasmacytoma Model
Molecular Therapys - Injuries in Women's International Ice Hockey: An 8-Year Study of the World Championship Tournaments and Olympic Winter Games
British Journal of Sports Medicine - ASXL1 and CBL Mutations are Independently Predictive of Inferior Survival in Advanced Systemic Mastocytosis
British Journal of Haematology - Characterization of FN1-FGFR1 and Novel FN1-FGF1 Fusion Genes in a Large Series of Phosphaturic Mesenchymal Tumors
Modern Pathology - Cyclin D1 Expression in Peripheral T-Cell Lymphomas
Modern Pathology - Profibrotic Up-Regulation of Glucose Transporter 1 by TGF-β Involves Activation of MEK and Mammalian Target of Rapamycin Complex 2 Pathways
The FASEB Journal - Effect of Chair Types on Work-Related Musculoskeletal Discomfort During Vaginal Surgery
American Journal of Obstetrics & Gynecology - Safety Studies for Use of Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells in a Rabbit Model for Osteoarthritis to Support a Phase I Clinical Trial
Stem Cells Translational Medicine - Common Fragile Sites (CFS) and Extremely Large CFS Genes are Targets for Human Papillomavirus Integrations and Chromosome Rearrangements in Oropharyngeal Squamous Cell Carcinoma
Genes Chromosomes Cancer - Frozen Section Analysis of SLNs in Trunk and Extremity Melanoma Has a High False Negative Rate but Can Spare Some Patients a Second Operation
Journal of Surgical Oncology - Ureaplasma Parvum Causes Hyperammonemia in a Pharmacologically Immunocompromised Murine Model
European Journal of Clinical Microbiology & Infectious Diseases - Transplacental Passage of Acetaminophen in Term Pregnancy
American Journal of Perinatology - Acute Kidney Injury in a Patient with Hemolytic Anemia and Thrombocytopenia
JAAPA - Breast Cancer Brain Metastases: Molecular Subtype, Treatment and Survival
Breast Disease - The Impact of Androgen Deprivation on Artificial Urinary Sphincter Outcomes
Translational Andrology and Urology