Mayo Clinic Laboratory and Pathology Research Roundup: Dec. 12

By Kelley Luedke • December 12, 2016

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Clear Cell Type A and B Molecular Subtypes in Metastatic Clear Cell Renal Cell Carcinoma: Tumor Heterogeneity and Aggressiveness

Intratumor molecular heterogeneity has been reported for primary clear cell renal cell carcinoma (ccRCC) tumors; however, heterogeneity in metastatic ccRCC tumors has not been explored. Mayo Clinic researchers conducted a study to evaluate intra- and intertumor molecular heterogeneity in resected metastatic ccRCC tumors. Primary and metastatic tumors were classified as clear cell type A (ccA) or B (ccB) subtypes. According to the results, approximately one quarter of metastatic tumors displayed intratumor heterogeneity; a similar rate of heterogeneity was observed across longitudinal metastatic tumors. For biomarker studies it is likely adequate to analyze a single sample per metastatic tumor provided that pathologic review is incorporated into the study design. Subtypes across patient-matched primary and metastatic tumors differed 43% of the time, suggesting that the primary tumor is not a good surrogate for the metastatic tumor. The study was published in European Urology.

Published to PubMed This Week

• Interphase Fluorescence in-situ Hybridization (iFISH) in Untreated AL Amyloidosis Has an Independent Prognostic Impact by Abnormality Type and Treatment Category
  Leukemia
• Bringing Microbial Diagnostics to the Clinic
  Clinical Infectious Diseases
• Clinical Reasoning: An Unusual Cause of Indeterminate Spells
  Neurology
• Paratesticular Adenomatoid Tumor
  Mayo Clinic Proceedings
• Passive Therapy with Humanized Anti-Staphylococcal Enterotoxin B Antibodies Attenuates Systemic Inflammatory Response and Protects from Lethal Pneumonia Caused by Staphylococcal Enterotoxin B-Producing Staphylococcus Aureus
  Virulence
• The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD)
  Journal of Biological Chemistry
• Multicenter Evaluation of a Modified Cefoxitin Disk Diffusion Method and PBP2a Testing to Predict mecA-mediated oxacillin resistance in atypical Staphylococcus aureus
  Journal of Biological Chemistry
• Characterization of the Oropharynx: Anatomy, Histology, Immunology, Squamous Cell Carcinoma & Surgical Resection
  Histopathology
• Increased Risk of Large-for-Gestational Age Birthweight in Singleton Siblings Conceived with in Vitro Fertilization in Frozen Versus Fresh Cycles
  Journal of Assisted Reproduction and Genetics
• A Kidney Transplant Recipient with Renal Medullary Viral Cytopathic Changes
  Transplant Infectious Disease
• Oral Progestogens Versus Levonorgestrel-Releasing Intrauterine System for Treatment of Endometrial Intraepithelial Neoplasia
  Journal of Women's Health
• Two-Year Results After Convective Radiofrequency Water Vapor Thermal Therapy of Symptomatic Benign Prostatic Hyperplasia
  Journal of Research and Reports in Urology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.