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Mayo Clinic Laboratory and Pathology Research Roundup: Dec. 26

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.


Featured Abstract

Differential Gene Expression Profiling of Matched Primary Renal Cell Carcinoma and Metastases Reveals Upregulation of Extracellular Matrix Genes

carcinoma_960x540The majority of renal cell carcinoma (RCC) studies analyze primary tumors, and the corresponding results are extrapolated to metastatic RCC tumors. However, it is unknown if gene expression profiles from primary RCC tumors differs from patient-matched metastatic tumors. Mayo Clinic researchers conducted a study to identify differentially expressed genes between patient-matched primary and metastatic RCC tumors in order to understand the molecular mechanisms underlying the development of RCC metastases. Researchers compared gene expression profiles between patient-matched primary and metastatic RCC tumors using a two-stage design. Affymetrix microarrays were assessed on 15 pairs of primary RCC (14 clear cell RCC, 1 papillary) tumors and patient-matched pulmonary metastases. Researchers also used custom Nanostring panel to validate seven candidate genes in an independent cohort of 114 clear cell RCC (ccRCC) patients. Researchers identified and validated up regulation of seven genes functionally involved in the formation of the extracellular matrix (ECM): DCN, SLIT2, LUM, LAMA2, ADAMTS12, CEACAM6 and LMO3. In primary ccRCC, CEACAM6, and LUM were significantly associated with metastasis-free and overall survival. The study implicates up regulation of ECM genes as a critical molecular event leading to visceral, bone, and soft tissue metastases in ccRCC. The study was published in Annals of Oncology.


Published to PubMed This Week

Kelley Luedke

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.