PathWays Case Study: Jan. 10

Image 1: Endoscopic Findings
Image 2: H&E 20X

A 48-year-old female presented with GI bleeding. CT scan revealed a mass measuring 2 cm located in the second part of the duodenum. Endoscopically, a polypoid nodule (Image 1) was identified. Histologically, two distinct morphologic areas were seen (Image 2). Immunohistochemical stains showed strong S100 expression in the spindled cell area (Image 2, top left) while the epithelioid area (Image 2, bottom right) expressed chromogranin A and synaptophysin.

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sayeedSadia Sayeed, M.D.
Fellow, Surgical Pathology
Mayo Clinic




Dr. Roger MoreiraRoger Moreira, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Associate Professor of Laboratory Medicine and Pathology,
Mayo Clinic College of Medicine

Rene Revier

Rene Revier

Rene Revier is an Editorial Assistant at Mayo Medical Laboratories. She supports Mayo Clinic PathWays and other corporate communications activities.