Mayo Clinic Laboratory and Pathology Research Roundup: Jan. 16

By Kelley Luedke • January 16, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

CDK4/6-Dependent Activation of DUB3 Regulates Cancer Metastasis through SNAIL1

Tumour metastasis, the spread of cancer cells from the original tumour site followed by growth of secondary tumours at distant organs, is the primary cause of cancer-related deaths and remains poorly understood. Mayo Clinic researchers demonstrated that inhibition of CDK4/6 blocks breast tumour metastasis in the triple-negative breast cancer model, without affecting tumour growth. Mechanistically, they identified a deubiquitinase, DUB3, as a target of CDK4/6; CDK4/6-mediated activation of DUB3 is essential to deubiquitinate and stabilize SNAIL1, a key factor promoting epithelial-mesenchymal transition and breast cancer metastasis. Overall, the study establishes the CDK4/6-DUB3 axis as an important regulatory mechanism of breast cancer metastasis and provides a rationale for potential therapeutic interventions in the treatment of breast cancer metastasis. The study was published in Nature Communications.

Published to PubMed This Week

• Microtubule Associated Protein (MAP) 1B: Novel Paraneoplastic Biomarker Running head: MAP 1B-IgG: Novel Paraneoplastic Biomarker
  Annals Neurology
• Best Practices for Monitoring Cardiac Troponin in Detecting Myocardial Injury
  Clinical Chemistry
• Miniaturized Nanopore DNA Sequencing: Accelerating the Path to Precision Medicine
  Clinical Chemistry
• Natriuretic Peptides and Analytical Barriers
  Clinical Chemistry
• Cervical Minimal Deviation Adenocarcinoma in Peutz-Jeghers Syndrome
  Mayo Clinic Proceedings
  
• Whole-Genome Sequencing in Healthy People
  Mayo Clinic Proceedings
• Fibrous Hamartoma of Infancy: A Clinicopathologic Study of 145 Cases, Including 2 With Sarcomatous Features
  Modern Pathology
• ACR Appropriateness Criteria Locally Advanced, High-Risk Prostate Cancer
  American Journal of Clinical Oncology
• Erratum to: Conserved Recurrent Gene Mutations Correlate With Pathway Deregulation and Clinical Outcomes of Lung Adenocarcinoma in Never-Smokers
  BMC Medical Genomics
• GAD65 Neurological Autoimmunity
  Muscle & Nerve
• Comprehensive Genomic Analysis of Metastatic Mucinous Urethral Adenocarcinoma Guides Precision Oncology Treatment: Targetable EGFR Amplification Leading to Successful Treatment With Erlotinib
  Clinical Genitourinary Cancer
• Plasma Mitochondrial DNA Levels Were Independently Associated With Lung Injury in Elderly Hip Fracture Patients
  Injury
• Improved Detection of Mineral Oil Toxicity Using an Extended Mouse Embryo Assay
  Journal of Assisted Reproduction and Genetics
• Primary Gastric Choriocarcinoma Presenting as a Pregnancy of Unknown Location
  Obstetrics & Gynecology
• Malignant Transformation of Biliary Adenofibroma: A Rare Biliary Cystic Tumor
  Journal of Gastrointestinal Oncology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.