Mayo Clinic Laboratory and Pathology Research Roundup: Jan. 23

By Kelley Luedke • January 23, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Renal Cell Carcinoma with Isolated Lymph Node Involvement: Long-Term Natural History and Predictors of Oncologic Outcomes Following Surgical Resection

Renal cell carcinoma (RCC) with isolated lymph node (LN) involvement has historically been associated with poor prognosis. However, a subset of patients may experience long-term survival. Mayo Clinic researchers conducted a study to examine the natural history of RCC with isolated LN involvement following surgical resection with long-term follow-up, and to evaluate clinicopathologic features associated with disease progression and survival. Metastasis-free survival, cancer-specific survival, and overall survival were estimated using the Kaplan-Meier method. Associations between clinicopathologic features and oncologic outcomes were evaluated using Cox regression models. Although isolated pN1 disease portends a poor prognosis, a small subset of patients experience durable long-term survival after surgical resection of isolated lymphatic metastases. Adverse prognostic features may enhance patient risk stratification and facilitate multimodal management approaches. The study was published in European Urology.

Published to PubMed This Week

• Recurrent GNAQ Mutations in Anastomosing Hemangiomas
  Modern Pathology
• Aberrant CDX2 Expression in Hepatocellular Carcinomas: An Important Diagnostic Pitfall
  Human Pathology
• FISH Identifies a KAT6A/CREBBP Fusion Caused by a Cryptic Insertional t(8;16) in a Case of Spontaneously Remitting Congenital Acute Myeloid Leukemia with a Normal Karyotype
  Pediatric Blood & Cancer
• Adenoid Cystic Carcinoma of the Lacrimal Gland is Frequently Characterized by MYB Rearrangement
  Eye
• Retained Surgical Sponge
  Cardiovascular Pathology
  
• The Impact of Prior Urethral Sling on Artificial Urinary Sphincter Outcomes
  Canadian Urological Association Journal

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.