Mayo Clinic Laboratory and Pathology Research Roundup: Feb. 6

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Alterations in the Immune Cell Composition in Premalignant Breast Tissue that Precede Breast Cancer Development

Little is known about the role of the immune system in the earliest stages of breast carcinogenesis. Mayo Clinic researchers studied quantitative differences in immune cell types between breast tissues from normal donors and women with benign breast disease (BBD). A breast tissue matched case-control study was created from donors to the Susan G. Komen® for the Cure Tissue Bank, and from women diagnosed with BBD at Mayo Clinic who either subsequently developed cancer (BBD cases) or remained cancer-free (BBD controls). According to the results, elevated infiltration of both innate and adaptive immune effectors in BBD tissues suggests an immunogenic microenvironment. The reduced B cell infiltration in women with later breast cancer suggests a role for B cells in preventing disease progression, and as a possible biomarker for breast cancer risk. The study was published in Clinical Cancer Research.

Published to PubMed This Week

Kelley Luedke (@kschrib)

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.