Mayo Clinic Laboratory and Pathology Research Roundup: Feb. 6

By Kelley Luedke • February 6, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Alterations in the Immune Cell Composition in Premalignant Breast Tissue that Precede Breast Cancer Development

Little is known about the role of the immune system in the earliest stages of breast carcinogenesis. Mayo Clinic researchers studied quantitative differences in immune cell types between breast tissues from normal donors and women with benign breast disease (BBD). A breast tissue matched case-control study was created from donors to the Susan G. Komen® for the Cure Tissue Bank, and from women diagnosed with BBD at Mayo Clinic who either subsequently developed cancer (BBD cases) or remained cancer-free (BBD controls). According to the results, elevated infiltration of both innate and adaptive immune effectors in BBD tissues suggests an immunogenic microenvironment. The reduced B cell infiltration in women with later breast cancer suggests a role for B cells in preventing disease progression, and as a possible biomarker for breast cancer risk. The study was published in Clinical Cancer Research.

Published to PubMed This Week

• Frontotemporal Dementia with the V337M MAPT Mutation: Tau-PET and Pathology Correlations
  Neurology
• Clinical, Biopsy, and Mass Spectrometry Findings of Renal Gelsolin Amyloidosis
  Kidney International
• Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography
  Radiology
• Evaluation of Copy-Number Variants as Modifiers of Breast and Ovarian Cancer Risk for BRCA1 Pathogenic Variant Carriers
  European Journal of Human Genetics
• Variability in Assigning Pathogenicity to Incidental Findings: Insights From LDLR Sequence Linked to the Electronic Health Record in 1013 Individuals
  European Journal of Human Genetics
  
• Mammographic Breast Density and Risk of Breast Cancer in Women with Atypical Hyperplasia: An Observational Cohort Study from the Mayo Clinic Benign Breast Disease (BBD) Cohort
  BMC Cancer
• Genetically Defined Oligodendroglioma is Characterized by Indistinct Tumor Borders at MRI
  American Journal of Neuroradiology
• Mantle Cell Lymphoma With a Novel t(11;12)(q13;p11.2): A Proposed Alternative Mechanism of CCND1 Upregulation
  Human Pathology
• Human Gongylonema pulchrum Infection: Esophageal Symptoms and Need for Prolonged Albendazole Therapy
  American Journal of Tropical Medicine and Hygiene
  
• Lymphoma Classification Update: T-Cell Lymphomas, Hodgkin Lymphomas, and Histiocytic/Dendritic Cell Neoplasms
  Expert Review of Hematology
• Profiling of Human Epigenetic Regulators Using a Semi-Automated Real-Time qPCR Platform Validated by Next Generation Sequencing
  Gene
• Role of the Common Fragile Sites in Cancers with a Human Papillomavirus Etiology
  Cytogenetic and Genome Research
  
• Artificial Urinary Sphincter Revision for Urethral Atrophy: Comparing Single Cuff Downsizing and Tandem Cuff Placement
  International Brazilian Journal Of Urology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.