Mayo Clinic Laboratory and Pathology Research Roundup: Feb. 13

By Kelley Luedke • February 13, 2017

Share this:

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Measurements and Models of Electric Fields in the In Vivo Human Brain During Transcranial Electric Stimulation

Transcranial electric stimulation aims to stimulate the brain by applying weak electrical currents at the scalp. However, the magnitude and spatial distribution of electric fields in the human brain are unknown. Mayo Clinic researchers measured electric potentials intracranially in ten epilepsy patients and estimated electric fields across the entire brain by leveraging calibrated current-flow models. When stimulating at 2 mA, cortical electric fields reached 0.4 V/m, the lower limit of effectiveness in animal studies. When individual whole-head anatomy is considered, the predicted electric field magnitudes correlated with the recorded values in cortical and depth electrodes. Accurate models require adjustment of tissue conductivity values reported in the literature, but accuracy is not improved when incorporating white matter anisotropy or different skull compartments. This is the first study to validate and calibrate current-flow models with in vivo intracranial recordings in humans, providing a solid foundation to target stimulation and interpret clinical trials. The study was published in eLife.

Published to PubMed This Week

• Antibody Prevalence in Epilepsy (APE) Score-Evolution in Autoimmune Epilepsy Practice
  JAMA Neurology
• Testicular Seminoma
  Mayo Clinic Proceedings
• Recurrent Copy Number Alterations in Low-Grade and Anaplastic Pleomorphic Xanthoastrocytoma With and Without BRAF V600E Mutation
  Brain Pathology
• Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer
  Scientific Reports
• Loss of p16^INK4A Expression and Homozygous CDKN2A Deletion are Associated with Worse Outcome and Younger Age in Thymic Carcinomas
  Journal of Thoracic Oncology
  
• Phenotypic and Molecular Antimicrobial Susceptibility of Helicobacter pylori
  Antimicrobial Agents and Chemotherapy
• Validation of a Vitamin D Replacement Strategy in Vitamin D-Insufficient Patients with Lymphoma or Chronic Lymphocytic Leukemia
  Blood Cancer Journal
• Effects of Cholecalciferol Supplementation on Serum and Urinary Vitamin D Metabolites and Binding Protein in HIV-infected Youth
  Journal of Steroid Biochemistry and Molecular Biology
• Can Intraneural Perineuriomas Occur Intradurally? An Anatomic Perspective
  Neurosurgery
  
• Usefulness for Predicting Cardiac Events After Orthotopic Liver Transplantation of Myocardial Perfusion Imaging and Dobutamine Stress Echocardiography Preoperatively
  American Journal of Cardiology
• Frozen Section Analysis of SLNs in Trunk and Extremity Melanoma Has a High False Negative Rate but Can Spare Some Patients a Second Operation
  Journal of Surgical Oncology
• The THOR Group and the Way (far) Forward: Transfusion Medicine Support is Vital to the Mission
  Transfusion
• Immunohistochemistry and Special Stains in Medical Liver Pathology
  Advances in Anatomic Pathology
• Expression of p63 Protein in Anaplastic Large Cell Lymphoma: Implications for Genetic Subtyping.
  Human Pathology
  
• Detection and Differentiation of Norovirus Genogroups I and II From Clinical Stool Specimens Using Real-Time PCR
  Diagnostic Microbiology and Infectious Disease
• Comparison of Two Double Red Cell Collection Settings on Fenwal Alyx Apheresis Instrument
  Journal of Clinical Apheresis
• Overlooked FANCD2 Variant Encodes a Promising, Portent Tumor Suppressor, and Alternative Polyadenylation Contributes to its Expression
  Oncotarget
• Autoimmune AQP4 Channelopathies and Neuromyelitis Optica Spectrum Disorders
  Handbook Clinical Neurology
• Autoimmune Autonomic Disorders
  Handbook Clinical Neurology
• Autoimmune Movement Disorders
  Handbook Clinical Neurology
• Beyond Moulage Sign and TTG Levels: The Role of Cross-Sectional Imaging in Celiac Sprue
  Abdominal Radiology
• Elevation of Cardiac Troponin T in Patients with Amyotrophic Lateral Sclerosis
  Acta Neurologica Belgica
• Risk of Delayed Lymph Node Metastasis in Clinically N0 Esthesioneuroblastoma
  Journal of Neurological Surgery. Part B, Skull Base
• Mass Spectrometry Applications for Toxicology
  EJIFCC

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.