PathWays Case Study: March 21

A 67-year-old woman presented with multiple episodes of gross hematuria. Urine cytology was consistent with malignancy and follow-up CT urogram demonstrated polypoid and sessile lesions in the bladder dome. The patient underwent cystectomy. Microscopy is shown below for two adjacent areas of tumor (area one—image 1, area two—images 2 & 3). Area two demonstrated diffuse positivity for synaptophysin and chromogranin.

Area One (10x)
Area Two (10x)
Area Two (40x)

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Matthew Woge, M.D.
Resident, Anatomic/Clinical Pathology
Mayo Clinic

Carrie Inwards, M.D.
Consultant, Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

Rene Revier (@renecre)

Rene Revier

Rene Revier is an Editorial Assistant at Mayo Medical Laboratories. She supports Mayo Clinic PathWays and other corporate communications activities.