A 58-year-old man presented with a growing, painful mass involving his right lower thigh. Pertinent clinical information included short stature, limb-length discrepancy, multiple enchondromas, and a hemangioma removed from his arm a few years ago. Imaging of the right lower extremity is shown (Figure 1). He was treated surgically with an above-the-knee amputation (gross, Figure 2). Histological features of the femoral lesion are shown below in Figure 3.
Alessia Buglioni, M.D.
Resident, Anatomic and Clinical Pathology
Mayo Clinic
Michael Rivera, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Sciences
Carrie Inwards, M.D.
Consultant, Division of Anatomic Pathology
Mayo Clinic
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine and Sciences