A 70-year-old female presented with peripheral blood lymphocytosis and hepatosplenomegaly. Below are the peripheral blood and bone marrow aspirate findings:
Karyotype cytogenetics revealed inv(14)(q11q32), with the rearrangement involving the TCL1 oncogene (confirmed by FISH).
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Basma Basha, M.D. Fellow, Hematopathology Mayo Clinic |
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Rebecca L. King, M.D. Consultant, Division of Hematopathology Mayo Clinic Assistant Professor of Laboratory Medicine and Pathology Mayo Clinic College of Medicine |