A 27-year-old woman with a history of ulcerative colitis and new onset pain and obstructive symptoms underwent ileocolectomy for a mass involving the cecum. Gross examination revealed a circumferential 9.5 cm mass with invasion through the muscularis propria. The tumor exhibited papillary architecture with fibrovascular cores, including sheets of crowded primitive appearing cells. Immunohistochemistry revealed immunoreactivity for CDX2 with rare reactivity for CK7 and CK20, and immunoreactivity for AE1/AE3, Glypican3, and SALL4, with patchy reactivity for AFP and CD30.
|Sara Cook, M.D., Ph.D.
Resident, Anatomic and Clinical Pathology
|Tsung-Teh Wu, M.D., Ph.D.
Consultant, Laboratory Medicine and Pathology
Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine