Hematopathology

A 61 year old man with a 1.5 year history of eosinophilia (absolute eosinophil count up to 32x109) undergoes a third bone marrow biopsy. Prior laboratory studies to evaluate for the etiology of eosinophilia have been negative. The current specimen reveals absolute eosinophilia with cytologic atypia on peripheral smear and bone marrow aspirate, a hypercellular bone marrow with megakaryocyte atypia.  Blasts are not increased. Cytogenetics revealed 46 XY del(3)(q21 )[19/20].

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Andres Madrigal, M.D., Ph.D.
Resident, Hematopathology
Mayo Clinic
Min Shi, M.D., Ph.D.
Consultant, Hematopathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

 

Clinical Chemistry

A 55-year-old female with history of eating disorder and high output ileostomy presented with electrolyte abnormalities, dehydration, chronic kidney failure, and severe QT prolongation. Initial serum lab evaluation revealed severe hypokalemia, hypochloremia, and hypermagnesemia. Stool studies revealed an osmotic cause of diarrhea with fecal osmotic gap of 204 mOsm/kg. Fecal sodium, potassium, chloride, magnesium, and phosphorous were 41 mmol/L, 2 mmol/L, 127 mmol/L, 231 mg/dL, and 3 mg/dL, respectively.

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Kornelia Galior, Ph.D.
Resident, Clinical Chemistry
Mayo Clinic
Darci Block, Ph.D.
Consultant, Laboratory Medicine and Pathology
Mayo Clinic
Assistant Professor of Laboratory Medicine and Pathology
Mayo Clinic College of Medicine

 

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Michelle Odean

Michelle Odean, Editorial Assistant at Mayo Clinic Laboratories, supports internal and client-facing communications. Outside of work, she enjoys running, rock climbing, yoga, and snuggling with her two bunnies.