Amyloid βeta Confirmed™ Program

Laboratory testing sponsored by Biogen and offered through Mayo Clinic Laboratories

About the program

Mayo Clinic Laboratories is proud to offer Alzheimer's disease biomarker testing as part of the Biogen-sponsored Amyloid βeta Confirmed™ Program. Participating providers will gain access to Mayo Clinic Laboratories' advanced cerebrospinal fluid (CSF) evaluation at no cost* to help broaden access and improve care planning for patients being evaluated for mild cognitive impairment (MCI) or mild dementia clinical stages of Alzheimer's disease.

To learn more about the program, please visit the program site.

 

*The Amyloid βeta Confirmed™ program will cover the cost of Aβ CSF laboratory testing only and does not cover the cost of the lumbar puncture procedure or any other related costs. The lumbar puncture procedure may be covered by the patient’s insurance provider. Because Biogen is paying for the cost of the test, health care providers must not seek reimbursement for the sponsored CSF test from the patient or any third-party payer, including but not limited to federal health care programs. This program is not intended to be an obligation or inducement to recommend, purchase, prescribe, promote, administer, use or support any Biogen product or to order medically unnecessary testing from Mayo Clinic Laboratories. Health care providers are responsible for ordering testing in accordance with their professional medical judgment and applicable laws. The program is subject to termination or modification at any time.

Answers to guide more informed decisions

When it comes to Alzheimer’s disease, early detection is important for disease management. We have developed a validated evaluation for Alzheimer’s disease, which uses CSF biomarkers to achieve a high concordance with amyloid positron emission tomography (PET) scan. Our test method reduces pre-analytical variability for diagnostic accuracy with each result. This new test also delivers fast results, providing timely answers to health care professionals and their patients.

By the numbers


1 day

of analytic time needed to perform test (turnaround time will range from 1 to 7 days depending on when the sample is received in the lab)


24/7

support from Mayo Clinic physicians and laboratorians

Get started

If you are already a Mayo Clinic Laboratories client, you can participate in the Amyloid βeta Confirmed Program using the steps below. If you are new to working with us, you must first register with your contact and institution information.

Note: If you are unsure whether your institution already works with Mayo Clinic Laboratories, please contact 800-533-1710 or mcl@mayo.edu to inquire. New to Mayo Clinic Laboratories? Click here to register.

Enroll online 

All providers must first enroll in the Amyloid βeta Confirmed Program. 

  • Enroll in the program and receive a personalized program registration code.
  • Store your registration code. This will be used for all orders placed through the program.
  • This is a one-time step.

Note: If your registration code is ever lost, simply re-enroll and receive a new code. 

Order testing

Use the same system you normally use to place orders with Mayo Clinic Laboratories (MayoLINK®, MayoACCESS®, or your laboratory information system). 

  • Order Biogen Program, Alzheimer’s Disease Evaluation, Spinal Fluid (Mayo ID: ADBIO). 
  • Enter your registration code when prompted by the Ask at Order Entry (AOE) question. 
  • Be sure to complete all other AOE questions. 

For paper orders, download Amyloid βeta Confirmed requisition form. 

Specimen collection

We require a specific polypropylene low-binding tube that has been shown to provide more accurate results for patients. 

Patient preparation: For 12 hours before specimen collection, do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins. 

Specimen volume: 2 mL 

 Collection instructions: 

  • Perform lumbar puncture and discard the first 1 to 2 mL of CSF. 
  • Collect 2 mL of CSF directly into CSF AD Biomarker Tube. Do not aliquot. Analysis needs to be performed using collection tube. 
    • Protocol recommends using drip method vs. syringe pull method.
  • Refrigerated (preferred), but frozen and ambient are also accepted when following specimen stability requirements.

Who do I contact for more information?

Telephone number

800-533-1710 or 507-266-5700  (available 24 hours) 

Email

mcl@mayo.edu

Health care providers are responsible for ordering testing in accordance with their professional medical judgment and applicable laws.

Neurology at Mayo Clinic


Mayo Clinic’s top-ranked team of neurologists diagnoses and treats more than 100,000 adults and children each year, including those with complex or rare conditions. 

The Mayo Clinic Department of Neurology is one of the largest and most comprehensive neurological practices in the world. It includes more than 200 subspecialized experts trained in epilepsy, movement disorders, dementias and other cognitive conditions, stroke and cerebrovascular diseases, neuro-oncology, multiple sclerosis and demyelinating disorders, autoimmune neurology, pediatric neurology, neurophysiology, headache, neuromuscular diseases, peripheral nerve, sleep neurology, and speech pathology. 

Neurology testing


Neurology testing is rapidly evolving, with increasing numbers of clinically relevant biomarkers discovered each year. Our laboratory collaborates closely with the practice and is designed to offer the most complex, clinically validated testing. Our disease experts support health care professionals in test selection and result interpretation to ensure proper test utilization and the highest quality of care. These physicians are committed to research and discovery to pave the way for the future of neurology testing.