Amyloidosis derived from leukocyte cell-derived chemotaxin 2 (ALECT2), a newly recognized form of amyloidosis, has already been established as a frequent form of systemic amyloidosis in the United States, with predominant involvement of the kidney and liver. Mayo Clinic researchers reviewed recent Mayo Clinic and non-Mayo Clinic studies to establish the clinicopathologic characteristics, incidence, and outcome of amyloidosis derived from ALECT2.
Dabigatran etexilate (Pradaxa), an oral, direct thrombin inhibitor, was approved in October 2010 by the U.S. Food and Drug Administration (FDA) for prevention of stroke and thrombosis in patients with nonvalvular atrial fibrillation (AF). In a recent article in Clinical Chemistry, Mayo Clinic researchers, Hemamalini Ketha, Ph.D., and John Mills, Ph.D., discuss whether dabigatran is a risk to patient safety.
Protocols for Mechanical Circulatory Support (MCS) often call for monitoring and titration of antiplatelet agents in the perioperative period. In this “Hot Topic,” Brad Karon, M.D., Ph.D., describes a study to identify the optimal platelet function tests for this purpose.
Mayo Clinic’s launch of eight new next-generation sequencing (NGS) panels is intended to improve the lives of patients and families living with inherited cardiac conditions by aiding in the diagnosis and management of these complex disorders. These disorders include hypertrophic cardiomyopathy, dilated cardiomyopathy, arrhythmogenic right ventricular cardiomyopathy, Noonan syndrome, Marfan syndrome, long QT syndrome, and Brugada syndrome.
A recent article in Clinical Lab Products, discusses various lipid screening approaches for cardiovascular disease, including Mayo Clinic’s use of Helena’s Spife system for the determination of Lp(a) levels.
Heart failure with preserved ejection fraction (HFpEF) is common and increasing in prevalence. Mayo Clinic researchers conducted a study in Circulation to test the hypothesis that cardiac hypertrophy, microvascular rarefaction and myocardial fibrosis are common and related in patients with HFpEF.
LDL cholesterol (LDL-C)3, an important modifiable risk factor for atherosclerotic cardiovascular disease, is primarily calculated via the Friedewald equation. However, a newly derived equation for LDL-C estimation was recently published that addressed limitations in the commonly used Friedewald LDL-C calculation method. Mayo Clinic researchers completed a study to evaluate the performance of a novel method to classify patients with superior concordance to measured LDL-C compared to the Friedewald method.
Lupus anticoagulants are associated with thrombosis, recurrent fetal loss, neurological problems, and cutaneous manifestations. Accurate diagnosis is important considering the potential use of long-term anticoagulant therapy because of the high risk of recurrent thrombosis.
Mayo Medical Laboratories is now performing NMR lipoprotein particle testing using the LipoScience, Inc. Vantera® Analyzer, which identifies and quantifies concentrations of lipoproteins using NMR spectroscopy and proprietary signal processing algorithms. Read more for full details and test information.
Allan Jaffe, M.D., a clinical cardiologist and professor of medicine and laboratory medicine and pathology at Mayo Clinic, was recently featured in February issue of CAP TODAY discussing his opinion on CVD risk markers. Dr. Jaffe also serves as chair of the Division of Clinical Core Laboratory Services in Mayo Clinic’s Department of Laboratory Medicine and Pathology. Read more for an excerpt from the front-page article, titled “Twilight zone for CVD risk markers?”
Heart failure is a complex cardiovascular disorder with a variety of etiologies and heterogeneity with respect to the clinical presentation of the patient. New biomarkers are available that can assist in the prognosis for patients already diagnosed with heart failure, and can aid in risk stratification, earlier detection of treatment failure, and therapeutic targets.
In this “Hot Topic,” Amy Saenger, Ph.D., DABCC, presents part 2 of a 3-part series on “Laboratory Test Utilization Strategies.” The series addresses strategies for test utilization in the clinical laboratory. This presentation will discuss some common clinical chemistry laboratory tests and strategies to direct appropriate use.
Heart valve infections are one of the complications of implanted cardiac devices. Mayo Clinic’s infectious disease experts are leaders in finding solutions to this problem, and their research has already changed medical practice and helped heart patients everywhere.