Genetics

An algorithm is a step-by-step procedure to guide clinicians and laboratorians in appropriate laboratory test ordering.

By brentwestra • August 13, 2015

The algorithm can be viewed here.

By brentwestra • August 8, 2015
The algorithm can be viewed here.
By brentwestra • August 7, 2015

The algorithm can be viewed here.

By brentwestra • August 7, 2015

Newborn screening (NBS) has developed throughout the years into a public health prevention program aimed at identifying an increasing number of conditions for which early intervention can prevent premature mortality, morbidity, and disabilities. In a recent article published in the journal Seminars in Perinatology, Mayo Clinic researchers reviewed the current state of NBS for lysosomal storage disorders and discussed their importance in NBS programs.

By Kelley Luedke • June 25, 2015

Mayo Clinic researchers conducted a study published in Clinical Cancer Research to determine whether there is a primary central nervous system lymphoma-specific genomic signature and, if so, how it differs from systematic diffuse large B-cell lymphomas.

By Kelley Luedke • June 25, 2015

Mayo Clinic researchers conducted a comprehensive evaluation of cis-acting eQTLs in the American Journal of Human Genetics by analyzing RNA-seq gene-expression data and genome-wide high-density genotypes.

By Kelley Luedke • June 24, 2015

Targeted next-generation sequencing has the potential to stratify a tumor by molecular subtype and aid the development of a biomarker profile for prognostic risk stratification and theranostic potential. Mayo Clinic researchers conducted a study in Gastrointestinal Endoscopy to assess the frequency and distribution of pathogenic alterations in malignant lymph node cytology specimens.

By Kelley Luedke • May 6, 2015

Fewer than five percent of people who die in hospitals are autopsied today. Autopsies are beneficial to discovering new advances in diseases, including cancer, dementia, and heart disease. In an article in the Wall Street Journal, Joseph Maleszewski, a cardiovascular pathologist at the Mayo Clinic in Rochester, Minn., discusses how “molecular autopsies” can provide useful information about a patient's genetics.

By Kelley Luedke • March 18, 2015

With the emergence of individualized medicine—treating a person as an individual and tailoring health care specific to that patient—developments in precision diagnostics are a critical driving force, especially via molecular testing. A recent study by Mayo Clinic researchers, published in the journal Human Pathology, aims to design and implement a scalable process that permits pre-appointment BRAF/KIT mutation analysis in melanoma patients.

By Kelley Luedke • March 17, 2015

The new RAS/RAF Targeted Gene Panel by Next Generation Sequencing, Tumor, test is now available to the Mayo Clinic practice and Mayo Medical Laboratories clients. In this post, Dr. Ande Rumilla discusses the clinical significance, proper ordering scenarios, and the science behind the test.

By brentwestra • January 13, 2015

Leica Biosystems and Mayo Clinic’s Department of Laboratory Medicine and Pathology announced today a collaboration to develop the next generation of cytogenetics imaging software.

By Andy Tofilon • December 15, 2014