Mayo Clinic and Mayo Medical Laboratories have signed a collaboration agreement with bioTheranostics to offer CancerTYPE ID® molecular cancer classification test, as part of its surgical pathology consultations, to aid in the management of patients with metastatic cancer.

By Kelley Luedke • November 4, 2013

Melanoma comprises only 10 percent of all skin cancers, but is responsible for approximately 90 percent of all skin-cancer mortality. Mayo Medical Laboratories’ melanoma FISH assay assists in the diagnosis of malignant melanoma, differentiating malignant melanoma from benign melanocytic lesions.

By Kelley Luedke • November 1, 2013

Systems engineers from the Mayo Clinic Department of Laboratory Medicine and Pathology (DLMP) were recently interviewed by “Clinic Lab Products” for its October coverage of Lean and Six Sigma laboratory solutions. Interviewed for the article were Rich Carlson and Matt A. Clark.

By Kelley Luedke • October 30, 2013

Clostridium difficile, an anaerobic spore-forming gram-positive bacillus, is the most important cause of antibiotic-associated diarrhea and pseudomembranous colitis. Polymerase chain reaction (PCR) assays have been developed to detect genetic markers in the PaLoc region of C difficile. While it is the most efficient direct method for laboratory diagnosis of C difficile infection, some laboratories may prefer the algorithmic approach using PCR as a confirmatory test for the presence of toxin.

By Kelley Luedke • September 1, 2013

Jaundice is a very common condition in newborn infants that is most often benign. However, acute and chronic bilirubin encephalopathy (acute or chronic neurologic damage resulting from high serum bilirubin levels) does still occur. Mayo Clinic used a screening algorithm to determine how to best use and interpret TcB values from healthy newborns.

By Kelley Luedke • July 1, 2013

Lyme disease is a tick-borne illness that is endemic in certain areas of the United States, including the Northeast and Upper Midwest. In several situations, laboratory testing is not recommended. However, laboratory diagnosis of Lyme disease is most commonly achieved by serologic testing, which should be limited to those persons with an appropriate exposure history and objective clinical findings. When serology is ordered, testing should be performed using the two-step approach as recommended by the CDC.

By Kelley Luedke • May 1, 2013

COLA, a leading laboratory accreditor, announced that it is expanding its educational offerings by collaborating with Mayo Medical Laboratories, a global reference laboratory operating within Mayo Clinic’s Department of Laboratory Medicine and Pathology. Under the agreement, COLA is now providing a convenient link to Mayo Medical Laboratories’ test utilization website directly from and the accreditor’s educational portal, Read more for full details.

By Mayo Clinic Laboratories • April 15, 2013

Mayo Laboratory Inquiry, the customer service center for Mayo Medical Laboratories, has recently been certified as a 2013 Center of Excellence by BenchmarkPortal, a global leader in the contact center industry, for the second year in a row.

By Mayo Clinic Laboratories • March 7, 2013

Rapid City Regional Hospital (RCRH), a 417 bed hospital located in the Black Hills of South Dakota, identified a marked increase in the use of blood products and associated costs at a time when blood components were in short supply. After hearing James Stubbs, M.D., medical director of transfusion medicine at Mayo Clinic Rochester, speak about best practices and the financial impact of transfusion medicine costs, RCRH implemented a blood management program to decrease blood usage.

By Kelley Luedke • March 1, 2013

A common ordering error among molecular tests is ordering a diagnostic test when a known-mutation test is indicated, and vice versa. Mayo Medical Laboratories offers tests to either diagnose the disease or determine if a previously identified genetic abnormality is present in a family member.

By Kelley Luedke • January 2, 2013

Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are nonspecific tests for acute inflammatory processes. Studies have demonstrated equivalent performance of ESR and CRP in a majority of patient populations, with the exception of patients with temporal arteritis and polymyalgia rheumatica. Mayo Clinic identified and evaluated patient populations where ESR and CRP were ordered concurrently to determine whether there was any added value to ordering both tests.

By Kelley Luedke • November 1, 2012

A recent review of Mayo Medical Laboratories test requests revealed an increase in orders for erythrocyte magnesium (Mg-RBC) and erythrocyte zinc (Zn-RBC). Discussions with health care providers ordering these tests indicate that Mg-RBC is used almost solely to assess nutritional status in diabetic patients. In this spotlight, Mayo Medical Laboratories investigated the utility of red blood cell testing.

By Kelley Luedke • September 1, 2012

Today’s clinical laboratory can offer a wide expanse of various genetic tests that can be requested by a clinician. The large repertoire of genetic testing services offered by Mayo Medical Laboratories can make selecting the appropriate test complicated. Mayo Clinic’s laboratory genetic counselors are available to help physicians select the most appropriate tests for their patients and reduce unnecessary testing.

By Kelley Luedke • May 1, 2012