NAM Archives - Insights Get the latest news and education from Mayo Clinic Laboratories Thu, 21 Aug 2025 17:52:26 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.1 Necrotizing Autoimmune Myopathy [Test in Focus] https://news.mayocliniclabs.com/2018/10/25/necrotizing-autoimmune-myopathy-a-test-in-focus/ https://news.mayocliniclabs.com/2018/10/25/necrotizing-autoimmune-myopathy-a-test-in-focus/#respond Thu, 25 Oct 2018 15:00:51 +0000 https://news.mayocliniclabs.com/?p=46818 Necrotizing Autoimmune Myopathy [Test in Focus]Necrotizing autoimmune myopathy (NAM) is a serious but rare muscle disease strongly associated with autoantibodies to either the protein signal recognition particle (SRP) or the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR). NAM typically manifests with subacute proximal limb muscle weakness and persistently elevated serum creatine kinase (CK) concentrations, but slower onsets can occur and complicate diagnosis.

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