Neuroimmunology Archives - Insights

Autoimmune Neurology: Phenotype-Based Testing

MCL Education — Wed, 03 Dec 2025 06:00:00 +0000

November 3, 2025 - In this video, Dr. Andrew McKeon describes how the field of autoimmune neurology testing has changed with the explosion of antibody discovery and discusses the importance of a patient-first, phenotype-based approach.

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New test distinguishes between prion disease and other causes of rapidly progressive dementia

Chris Bahnsen — Mon, 03 Feb 2025 14:00:00 +0000

Performed on cerebrospinal fluid, Mayo Clinic’s RT-QuIC prion test can distinguish prion disease from other types of rapidly progressive dementias to enhance patient care.

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Unraveling a diagnostic mystery: Ed Garber

Cory Pedersen — Mon, 05 Dec 2022 14:00:00 +0000

Ed Garber spent months in physical and neurological decline while a cohort of care providers and specialists searched for the root cause of his symptoms. That search for answers ended after testing by Mayo Clinic Laboratories gave them the confirmatory diagnosis they needed.

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Kelch-like protein 11 autoantibodies: A novel biomarker of testicular cancer associated neurological autoimmunity

MCL Education — Thu, 22 Jul 2021 06:00:00 +0000

The discovery of Kelch like protein 11 (KLHL11) IgG as a specific biomarker of neurological autoimmunity associated testicular germ cell tumor.

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Behind the scenes in neural antibody testing

MCL Education — Mon, 14 Dec 2020 13:30:11 +0000

In this month’s “Hot Topic,” John Mills, Ph.D., explains the central role of tissue immunofluorescence in the identification of neural antibodies and discusses the benefits of an integrated laboratory approach to the development and validation of novel antibody biomarkers.

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Pediatric CNS Disorder Evaluations [Test in Focus]

Alyssa Frank — Tue, 04 Feb 2020 17:01:00 +0000

Autoimmune encephalitis and myelitis is increasingly recognized as a cause of CNS disease in children and teens. Andrew McKeon, M.B., B.Ch., M.D, gives an overview of this test available through Mayo Clinic Laboratories. He discusses when this testing should be ordered, how this testing compares to other testing approaches, and what clinical action can be taken due to the results of this testing.

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GFAP: Novel Test for a Newly Identified Meningoencephalomyelitis

Barbara J. Toman — Fri, 28 Jun 2019 16:00:17 +0000

Mayo Clinic Laboratories is the only laboratory in the world to offer testing for a novel form of autoimmune meningoencephalomyelitis. Known as autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy, the condition was identified by Mayo Clinic in 2016. The GFAP antibody test is offered as part of Mayo Clinic Laboratories’ encephalitis and myelopathy evaluations.

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Beyond the Test Result: Greg Widseth

Mayo Clinic Laboratories — Tue, 20 Dec 2016 19:31:06 +0000

Greg Widseth was suddenly hit by a rare disease that prompted his immune system to attack his brain cells, resulting in as many as 60 seizures a day. Special blood and spinal fluid tests developed by Mayo Medical Laboratories confirmed that Widseth had antibodies known to target certain brain cells.

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