Research

This week's research roundup feature: Given the prevalence of dementia and the development of pathology-specific disease modifying therapies, high-value biomarker strategies to inform medical decision making are critical. In-vivo tau positron emission tomography (PET) is an ideal target as a biomarker for Alzheimer's disease diagnosis and treatment outcome measure.

This week's research roundup feature: Membranous nephropathy (MN) is a pattern of injury caused by autoantibodies binding to specific target antigens, with accumulation of immune complexes along the subepithelial region of glomerular basement membranes.

This week's research roundup feature: Gene fusions involving tumor protein p63 gene (TP63) occur in multiple T and B cell lymphomas and portend a dismal prognosis for patients. The function and mechanisms of TP63 fusions remain unclear, and there is no target therapy for patients with lymphoma harboring TP63 fusions. Here, we show that TP63 fusions act as bona fide oncogenes and are essential for fusion-positive lymphomas.

This week's research roundup feature: Semaglutide in HFpEF across obesity class and by body weight reduction.

This week's research roundup feature: There is a need to develop safe and effective pharmacologic options for the treatment of celiac disease (CeD); however, consensus on the appropriate design and configuration of randomized controlled trials (RCTs) in this population is lacking.

This week's research roundup feature: Activated mast cells in periprosthetic joint infection-associated tissue.

This week's research roundup feature: 16S rRNA gene PCR/Sequencing of heart valves for diagnosis of infective endocarditis in routine clinical practice.

This week's research roundup feature: Association of plasma biomarkers of Alzheimer Disease with cognition and medical comorbidities in a biracial cohort.

This week's research roundup feature: Gain-of-function mutant p53 together with ERG proto-oncogene drive prostate cancer by beta-catenin activation and pyrimidine synthesis.

This week's research roundup feature: Age-based versus young-adult thresholds for nephrosclerosis on kidney biopsy and prognostic implications for CKD.

This week's research roundup feature: A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling.

This week's research roundup feature: The clinical and molecular spectrum of ETV6 mutated myeloid neoplasms.

This week's research roundup feature: Natural history, predictors of development of extramedullary disease, and treatment outcomes for patients with extramedullary multiple myeloma.