A Case-Based Workshop: Clinical and Laboratory Aspects of Hemophilia and Thrombosis

Friday Symposium Preceding the 62nd American Society of Hematology Annual Meeting

Live program originally presented on December 4, 2020


This program’s overall objective is to inform participants about emerging diagnostic and therapeutic aspects of bleeding and thrombotic disorders. Topics discussed will include:

  • Choosing the right type of factor assays for monitoring newer factor and non-factor products for hemophilia management.
  • The optimal role of newer technologies like next-generation sequencing for diagnosis of coagulation disorders.
  • The optimal laboratory evaluation of inherited platelet disorders.
  • An update on recent advances in the diagnosis of heparin-induced thrombocytopenia.
  • The role of measuring direct-acting oral anticoagulants.

Using test-ordering algorithms based on data derived from the Mayo Clinic Special Coagulation Laboratory practice and the literature, we will illustrate how costly and unnecessary biochemical, phenotypic, and genetic testing can be avoided in the participants’ practices while enhancing highest quality medical care.

Intended Audience

Hematologists, oncologists, pathologists, nurse practitioners, physician assistants, nurses, and laboratory scientists.



Upon completion of the conference, participants should be able to:

  • Recount the novel agents for management of hemophilia.
  • Identify the optimal assay for monitoring novel agents in hemophilia management.
  • Efficiently and cost-effectively utilize laboratory tests in the evaluation of patients with suspected heparin-induced thrombocytopenia.
  • Determine when and how to pursue platelet esoteric testing to diagnose congenital platelet disorders.
  • Discuss a practical approach to utilizing next-generation sequencing technology in coagulation disorders.
  • Identify the appropriate indication for measurement of direct-acting anticoagulants and their utility in patient management.

Level of Instruction



Ana Casanegra, M.D.
Associate Professor of Medicine
Division of Cardiovascular Diseases
Mayo Clinic, Rochester, MN
Photo of Anand Padmanabhan, M.B.B.S., Ph.D. Anand Padmanabhan, M.B.B.S., Ph.D.
Divisions of Hematopathology and Transfusion Medicine
Mayo Clinic, Rochester, MN
Photo of Dong Chen, M.D., Ph.D. Dong Chen, M.D., Ph.D.
Professor of Laboratory Medicine and Pathology
Division of Hematopathology
Mayo Clinic, Rochester, MN
Photo of Rajiv K. Pruthi, M.B.B.S. Rajiv Pruthi, M.B.B.S.
Associate Professor of Laboratory Medicine and Pathology
Division of Hematology
Mayo Clinic, Rochester, MN

Faculty Disclosure

As a provider accredited by ACCME, Mayo Clinic College of Medicine and Science (Mayo Clinic School of Continuous Professional Development) must ensure balance, independence, objectivity, and scientific rigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty members also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentations. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentations.


New Therapies for Hemophilia: Options and Assays

Presented by: Rajiv Pruthi, M.B.B.S.

Presentation handout (PDF)

Advances in the Diagnosis of Heparin Induced Thrombocytopenia

Presented by: Anand Padmanabhan, M.B.B.S., Ph.D.

Presentation handout (PDF)

Platelet Esoteric Testing: When and Why

Presented by: Dong Chen, M.D., Ph.D.

Presentation handout (PDF)

Rationale Application of Next Generation Sequencing Technologies in Coagulation Disorders

Presented by: Rajiv Pruthi, M.B.B.S.

Presentation handout (PDF)

Measurement of Direct Acting Anticoagulants: Clinical and Laboratory Issues

Presented by: Ana Casanegra, M.D.

Presentation handout (PDF)


Contact the Education Department at 800-533-1710 or 507-284-3156 or email mcleducation@mayo.edu.