Topic highlights include: Mayo Clinic doctors weigh in on all things back-to-school, Trial seeks to develop first Lyme disease vaccine in 2 decades, New York health department says hundreds of people may be infected with polio virus.

In this episode, Dr. Pritt and Dr. Morice discuss new developments in monkeypox testing, updates on the federal response, and lessons learned from managing other viruses.

In a recent study, Mayo Clinic researchers developed the first cellular DNA barcoding with a machine-learning approach to reveal previously unknown metastatic behavior of tumor cells. Researchers barcoded the DNA of millions of human ovarian cancer cells and transplanted them in mice, where rare tumor initiating cells and their progenies could be tracked within the primary tumor as well as in every other organ they were spreading into. The entire community of cells generated by a single barcoded cell had identical barcodes. This enabled the tracking of a large number of benign and metastatic clones by sequencing DNA barcodes in tumors and various organs, including blood and ascites. Using the cellular DNA barcoding approach and a newly developed data analysis system, researchers could track clonal growth dynamics in various metastatic sites and trace it back to its ancestral tumor-initiating cell. They used artificial intelligence to tackle the complex data to identify if the clonal metastatic spread is happening peritoneally or through blood routes.

This week's research roundup features: Type 1, type 2 myocardial infarction and non-ischemic myocardial injury-opinion from the front lines

Rong He, M.D., describes how Mayo Clinic Laboratories’ NPM1Q assay detects all known forms of a genetic mutation found in about 30% of people with acute myeloid leukemia, or AML. Identifying the NPM1 mutation is critical for clinical decision-making.

At just 24-years-old Anya Magnuson has survived not just one but two close encounters with death. Focused, determined, and intent on experiencing life to its fullest, Anya never gave up. Nor did the multidisciplinary Mayo Clinic care team who worked tirelessly to heal her.

Over the course of two days, Mayo Clinic’s 2022 Breast Cancer Care: Innovation, Disruptive Technologies and Early Adopters educational conference will bring you up to speed on the new therapeutics, technologies and techniques that could change the way you provide breast cancer care.

Topic highlights include: Mayo: urgent need for O- blood types, Optum, Sanofi team to make low-cost insulin available to uninsured, How the COVID-19 pandemic changed Americans’ health for the worse.

In this episode of “Lab Medicine Rounds,” Justin Kreuter, M.D., sits down with Bobbi Pritt, M.D., professor of Laboratory Medicine and Pathology and division chair for the Department of Clinical Microbiology at Mayo Clinic, to discuss why this year’s tick season is more severe than others.

John Osborn, operations administrator in the Department of Laboratory Medicine and Pathology at Mayo Clinic, joins the "Answers From the Lab" podcast for a discussion with host Bobbi Pritt, M.D. about monkeypox testing. In this episode, John and Dr. Pritt discuss how Mayo Clinic swiftly operationalized monkeypox testing and the challenges involved with supporting the new assay, including staffing.

In July 2022, Mayo Clinic Laboratories announced fifteen new tests along with numerous reference value changes, obsolete tests, and algorithm changes.

Todd Walker is a laboratory supervisor for Mayo Clinic Laboratories, Specimen Operations, where he helps lead the department that serves as the gateway between collecting and delivering specimens and getting them processed. Todd credits his diverse, agile team and the impressive global logistics infrastructure that allows them to support the processing of 40,000 specimens in a day.

Rajiv Pruthi, M.B.B.S., explains how Mayo Clinic Laboratories’ serotonin release assay achieves high sensitivity and specificity while avoiding the use of radioactive materials. Serotonin release testing is an important tool in the diagnosis of heparin induced thrombocytopenia, or HIT, which can have devastating consequences for patients.

This week's research roundup features: Gastrointestinal stromal tumors mimicking gynecologic disease: clinicopathological analysis of 20 cases.

This page includes updates posted to mayocliniclabs.com during the month of July.