Mayo Clinic Laboratory and Pathology Research Roundup: March 6

By Kelley Luedke • March 6, 2017

Share this:

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Outcomes of Warfarin Therapy for Bioprosthetic Valve Thrombosis of Surgically Implanted Valves: A Prospective Study

Mayo Clinic researchers conducted a study to assess the efficacy of warfarin in the treatment of bioprosthetic valve thrombosis (BPVT) of surgically implanted valves. Fifty-two patients were enrolled in the study. Prosthesis positions were aortic in 31 patients, mitral in 17, pulmonary in 2, and tricuspid in 2. Positive responses (defined as a 50% reduction in prosthesis gradient) occurred in 43 patients within 11 weeks of anticoagulation with warfarin. Nine patients did not respond to warfarin, and these patients underwent surgical valve replacement, transcatheter valve replacement, and intervention. BPVT scores were calculated for 48 patients with good-quality echocardiographic images; 9 had BPVT scores of 2, and 39 had BPVTs score of 3. A BPVT score of 3 predicted a positive response to anticoagulation therapy with sensitivity of 88% and specificity of 93%. A trial of anticoagulation was effective in 83% of patients with suspected BPVT, and most patients responded within 3 months. BPVT score was predictive of response to therapy and should be considered during patient selection. The study was published in JACC Cardiovascular Interventions.

Published to PubMed This Week

• Fatty Acid Synthase Regulates Estrogen Receptor-α Signaling in Breast Cancer Cells
  Oncogenesis
• Composition of Single-Step Media Used for Human Embryo Culture
  Fertility and Sterility
• A Longitudinal Study of Whole Body, Tissue and Cellular Physiology in a Mouse Model of Fibrosing NASH with High Fidelity to the Human Condition
  AJP Gastrointestinal and Liver Physiology
• Immunohistochemistry and Special Stains in Medical Liver Pathology
  Advances in Anatomic Pathology
• The Nearly Invisible Intraneural Cyst: A New and Emerging Part of the Spectrum
  Neurosurgical Focus
• Technical Note: Insertion of Digital Lesions in the Projection Domain for Dual Source, Dual Energy CT
  Medical Physics Online
• Profiling of Human Epigenetic Regulators Using a Semi-Automated Real-Time qPCR Platform Validated by Next Generation Sequencing
  Gene
• Total Red Blood Cell Transfusions for Chronic Hemodialysis Patients in a Single Center, 2009-2013
  Nephron
• Increased Risk of Hospitalization for Ultrarapid Metabolizers of Cytochrome P450 2D6
  Journal of Pharmacogenomics and Personalized Medicine

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.