Mayo Clinic Laboratory and Pathology Research Roundup: April 17
The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Featured Abstract
Autologous Mesenchymal Stem Cells, Applied in a Bioabsorbable Matrix, for Treatment of Perianal Fistulas in Patients With Crohn's Disease
In patients with Crohn's disease, perianal fistulas frequently recur, causing substantial morbidity. Mayo Clinic researchers performed a 12 patient, 6 month phase I trial to determine whether autologous mesenchymal stem cells (MSCs), applied in a bioabsorbable matrix, can heal the fistula. Fistula repair was not associated with any serious adverse events related to MSCs or plug placement. At 6 months, 83% of patients had complete clinical healing and radiographic markers of response. Researchers found placement of MSC-coated matrix fistula plugs in 12 patients with chronic perianal fistulas to be safe and lead to clinical healing and radiographic response in 10 patients. The study was published in Gastroenterology.
Published to PubMed This Week
- Branchial Cleft Cyst in Lateral Neck of an Adult
Mayo Clinic Proceedings - CD49d Associates with Nodal Presentation and Subsequent Development of Lymphadenopathy in Patients with Chronic Lymphocytic Leukaemia
British Journal of Haematology
- MAGE-TRIM28 Complex Promotes the Warburg Effect and Hepatocellular Carcinoma Progression by Targeting FBP1 for Degradation
Oncogenesis - EGFR-Induced Phosphorylation of Type Iγ Phosphatidylinositol Phosphate Kinase Promotes Pancreatic Cancer Progression
Oncotarget - Akt inhibitor MK-2206 in combination with Bendamustine and Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia: Results from the N1087 Alliance Study
American Journal of Hematology - Severity of Preoperative Proteinuria is a Risk Factor for Overall Mortality in Patients Undergoing Nephrectomy
Journal of Urology - Comparison of Two Whole-Genome Sequencing Methods for Analysis of Three Methicillin-Resistant <i>Staphylococcus aureus</i> Outbreaks
Journal of Clinical Microbiology - Multicenter Performance Assessment of the Carba NP Test
Journal of Clinical Microbiology - Update on Malaria Diagnostics and Test Utilization
Journal of Clinical Microbiology - Genotypic analysis of <i>Tropheryma whipplei</i> from patients with Whipple disease in the Americas
Journal of Clinical Pathology - Serodiagnosis of Dengue Virus Infection Using Commercially Available Antibody and NS1 Antigen ELISAs
Diagnostic Microbiology and Infectious Disease - Lymphoma Classification Update: B-Cell Non-Hodgkin Lymphomas
Expert Review of Hematology - Offering Prenatal Screening in the Age of Genomic Medicine: A Practical Guide
Journal of Women's Health - Neuroendocrine Tumors of the Breast
Endocrine Pathology - Vision Loss, Rash, and Abnormal Brain Magnetic Resonance Imaging in a 17 Year Old
Abdominal Radiology - Implementation of a Software Application for Presurgical Case History Review of Frozen Section Pathology Cases
Journal of Pathology Informatics - A Virtual Clinical Trial Using Projection-Based Nodule Insertion to Determine Radiologist Reader Performance in Lung Cancer Screening CT
Proceedings of SPIE