Mayo Clinic Laboratory and Pathology Research Roundup: May 1

By Kelley Luedke • May 1, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Association of Postoperative High-Sensitivity Troponin Levels with Myocardial Injury and 30-Day Mortality among Patients Undergoing Noncardiac Surgery

Little is known about the relationship between perioperative high-sensitivity troponin T (hsTnT) measurements and 30-day mortality and myocardial injury after noncardiac surgery (MINS). Mayo Clinic researchers conducted a study to determine the association between perioperative hsTnT measurements and 30-day mortality and potential diagnostic criteria for MINS. A modified Mazumdar approach was used to determine if there were hsTnT thresholds associated with risk of death and had an adjusted hazard ratio of 3.0 or higher and a risk of 30-day mortality of 3% or higher. To determine potential diagnostic criteria for MINS, regression analyses ascertained if postoperative hsTnT elevations required an ischemic feature (eg, ischemic symptom or electrocardiography finding) to be associated with 30-day mortality. Based on the results, among patients undergoing noncardiac surgery, peak postoperative hsTnT during the first 3 days after surgery was significantly associated with 30-day mortality. Elevated postoperative hsTnT without an ischemic feature was also associated with 30-day mortality. The study was published in JAMA.

Published to PubMed This Week

• Pembrolizumab in Patients with Chronic Lymphocytic Leukemia with Richter's Transformation and Relapsed CLL
  Blood
• Tau Aggregation Influences Cognition and Hippocampal Atrophy in the Absence of Beta-Amyloid: A Clinico-Imaging-Pathological Study of Primary Age-Related Tauopathy (PART)
  Acta Neuropathologica
  
• Pathology, Imaging, and Treatment of Cardiac Tumours
  Nature Reviews Cardiology
• Diagnostic Performance of MR Elastography and Vibration-controlled Transient Elastography in the Detection of Hepatic Fibrosis in Patients with Severe to Morbid Obesity
  Radiology
• High Prevalence of Monoclonal Gammopathy Among Patients with Warm Autoimmune Hemolytic Anemia
  American Journal of Hematology
• The Utility of MASS-FIX to Detect and Monitor Monoclonal Proteins in the Clinic
  American Journal of Hematology
• Alveolar Soft Part Sarcoma of the Female Genital Tract: A Morphologic, Immunohistochemical, and Molecular Cytogenetic Study of 10 Cases With Emphasis on its Distinction From Morphologic Mimics
  American Journal of Surgical Pathology
• Liver Function Test Abnormalities and Their Clinical Relevance in Primary Myelofibrosis
  Blood Cancer Journal
• Whole-Exome Analysis Reveals Novel Somatic Genomic Alterations Associated with Cell of Origin in Diffuse Large B-Cell Lymphoma
  Blood Cancer Journal
• Serologic Testing for Zika Virus: Comparison of Three Zika Virus IgM ELISAs and Initial Laboratory Experiences
  Journal of Clinical Microbiology
• The Brief Case: Crusted Scabies in a Leukemic Patient following a Stay in a Long-Term Acute Care Facility
  Journal of Clinical Microbiology
• Closing the Brief Case: Crusted Scabies in a Leukemic Patient following a Stay in a Long-Term Acute Care Facility
  Journal of Clinical Microbiology
• Prognostic Significance of Lymphatic, Vascular and Perineural Invasion for Bladder Cancer Patients Treated by Radical Cystectomy
  Pathology
• Malignant Transformation of Polyostotic Fibrous Dysplasia with Aberrant Keratin Expression
  Human Pathology
• Evaluation of a Real-Time PCR Assay for Rectal Screening of OXA-48-Producing Enterobacteriaceae in a General Intensive Care Unit of an Endemic Hospital
  Diagnostic Microbiology and Infectious Disease
• Lack of Utility of Anti-tTG IgG to Diagnose Celiac Disease When Anti-tTG IgA Is Negative
  Journal of Pediatric Gastroenterology and Nutrition
• First report of MYD88^L265P Somatic Mutation in IgM-Associated Light Chain Amyloidosis
  Amyloid
• Lipid Biomarkers for Risk Assessment in Acute Coronary Syndromes
  Current Cardiology Reports
• High-Throughput Processing to Preserve Viable Cells: A Precision Medicine Initiative Cohort Program Workshop
  Biopreservation and Biobanking
• Characterization of Relative Biological Effectiveness for Conventional Radiation Therapy: A Comparison of Clinical 6 MV X-rays and 137Cs
  Journal of Radiation Research
• Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission
  EBioMedicine
• Association of DNA Mismatch Repair and Mutations in BRAF and KRAS With Survival After Recurrence in Stage III Colon Cancers : A Secondary Analysis of 2 Randomized Clinical Trials
  JAMA Oncology
• A Systems Biology Approach to Investigating the Influence of Exercise and Fitness on the Composition of Leukocytes in Peripheral Blood
  Journal for ImmunoTherapy of Cancer
• Experience with Precision Genomics and Tumor Board, Indicates Frequent Target Identification, but Barriers to Delivery
  Oncotarget
• Osteosclerosis Secondary to Metastatic Oligodendroglioma
  Rare Tumors

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.