Mayo Clinic Laboratory and Pathology Research Roundup: May 8
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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Featured Abstract
AKT-Phosphorylated FOXO1 Suppresses ERK Activation and Chemoresistance by Disrupting IQGAP1-MAPK Interaction
Nuclear FOXO proteins act as tumor suppressors by transcriptionally activating genes involved in apoptosis and cell cycle arrest, and these anticancer functions are inhibited by AKT-induced phosphorylation and cytoplasmic sequestration of FOXOs. Mayo Clinic researchers found that, after AKT-mediated phosphorylation at serine 319, FOXO1 binds to IQGAP1, a hub for activation of the MAPK pathway, and impedes IQGAP1-dependent phosphorylation of ERK1/2 (pERK1/2). Conversely, decreased FOXO1 expression increases pERK1/2 in cancer cell lines and correlates with increased pERK1/2 levels in patient specimens and disease progression. Treatment of cancer cells with PI3K inhibitors or taxane causes FOXO1 localization in the nucleus, increased expression of pERK1/2, and drug resistance. These effects are reversed by administering a small FOXO1-derived phospho-mimicking peptide inhibitor in vitro and in mice. The results show a tumor suppressor role of AKT-phosphorylated FOXO1 in the cytoplasm and suggest that this function of FOXO1 can be harnessed to overcome chemoresistance in cancer. The study was published in the EMBO Journal.
Published to PubMed This Week
- Autoantibody-Induced Internalization of CNS AQP4 Water Channel and EAAT2 Glutamate Transporter Requires Astrocytic Fc Receptor
Proceedings of the National Academy of Sciences - Autologous Mesenchymal Stem Cells Increase Cortical Perfusion in Renovascular Disease
Journal of the American Society of Nephrology
- Recessive TAF1A Mutations Reveal Ribosomopathy in Siblings with End-Stage Pediatric Dilated Cardiomyopathy
Human Molecular Genetics - Risk of Histological Transformation and Therapy-Related Myelodysplasia/Acute Myeloid Leukaemia in Patients Receiving Radioimmunotherapy for Follicular Lymphoma
British Journal of Haematology - Type Iγ Phosphatidylinositol Phosphate Kinase Regulates PD-L1 Expression by Activating NF-κB
Oncotarget - EGFR Mediates Activation of RET in Lung Adenocarcinoma with Neuroendocrine Differentiation Characterized by ASCL1 Expression
Oncotarget - Concomitant Disruption of <i>CD4</i> and <i>CD8</i> Genes Facilitates the Development of Double Negative αβ TCR<sup>+</sup> Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen
Journal of Immunology - Non-BRCA Familial Breast Cancer: Review of Reported Pathology and Molecular Findings
Pathology - Comparison of Turnaround Time and Total Cost of HIV Testing Before and After Implementation of the 2014 CDC/APHL Laboratory Testing Algorithm for Diagnosis of HIV Infection
Journal of Clinical Virology - Diagnostic Testing Approaches for Activated Protein C Resistance and Factor V Leiden: A Comparison of Institutional and National Provider Practices
American Journal of Clinical Pathology - Histologic Evaluation of Micronized AlloDerm After Injection Laryngoplasty in a Rabbit Model
Laryngoscope - The Expression and Clinical Relevance of PD-1, PD-L1, and TP63 in Patients with Diffuse Large B-Cell Lymphoma
Medicine - Oral Progestogens Versus Levonorgestrel-Releasing Intrauterine System for Treatment of Endometrial Intraepithelial Neoplasia
Journal of Women's Health - Macular Edema is a Rare Finding in Untreated Vitreoretinal Lymphoma: Small Case Series and Review of the Literature
International Journal of Retina and Vitreous - Hepatic Segmental Atrophy and Nodular Elastosis: Imaging Features
Abdominal Radiology
