Mayo Clinic Laboratory and Pathology Research Roundup: June 5

By Kelley Luedke • June 5, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Oncologic Outcomes for Patients with Residual Cancer at Cystectomy Following Neoadjuvant Chemotherapy: A Pathologic Stage-Matched Analysis

While it has been demonstrated that receipt of neoadjuvant chemotherapy (NAC) before radical cystectomy improves survival compared to radical cystectomy alone, the driving factor for this benefit may be from patients with ypT0 status at surgery. Meanwhile, the implications of having residual urothelial carcinoma of the bladder at radical cystectomy after neoadjuvant chemotherapy are less clear. Mayo Clinic researchers evaluated whether survival differed between patients with residual urothelial carcinoma of the bladder at radical cystectomy after NAC and stage-matched controls who underwent radical cystectomy alone. On surgical removal of the bladder, patients without residual bladder cancer after neoadjuvant chemotherapy have excellent survival outcomes. However, patients with residual cancer after neoadjuvant chemotherapy and surgery have worse outcomes compared to patients undergoing surgery alone. These patients should therefore be considered for additional treatments after surgery using newer agents while we await further research on predicting which patients will benefit from neoadjuvant chemotherapy before bladder removal for cancer. The study was published in European Urology.

Published to PubMed This Week

• Synchronous Gemistocytic Astrocytoma IDH-mutant and Oligodendroglioma IDH-mutant and 1p/19q-codeleted in a Patient with CCDC26 Polymorphism
  Acta Neuropathologica
• A Woman in Her 60s With Chronic Meningitis
  JAMA Neurology
  
• Nonsteroidal Anti-Inflammatory Drug-Induced Protein-Losing Enteropathy: A Great Masquerade of Crohn's Disease
  Gastrointestinal Endoscopy
• Accuracy of Capillary and Arterial Whole Blood Glucose Measurements Using a Glucose Meter in Patients under General Anesthesia in the Operating Room
  Anesthesiology
• White-matter Integrity on DTI and the Pathologic Staging of Alzheimer's Disease
  Neurobiology of Aging
• Predictive Models in the Diagnosis and Treatment of Autoimmune Epilepsy
  Epilepsia
• Quinacrine in Endometrial Cancer: Repurposing an Old Antimalarial Drug
  Gynecologic Oncology
• Inversion 3 Cytogenetic Abnormality in an Allogeneic Hematopoietic Cell Transplant Recipient Representative of a Donor Derived Constitutional Abnormality
  Biology of Blood and Marrow Transplantation
• Zinc and the Iron Donor Frataxin Regulate Oligomerization of the Scaffold Protein to Form New Fe-S Cluster Assembly Centers
  Metallomics
• Amphotericin-impregnated Polymethylmethacrylate Beads as Treatment for Soft Tissue Mucormycosis
  Surgery
• Diagnostic Utility of IDH1/2 Mutations to Distinguish Dedifferentiated Chondrosarcoma from Undifferentiated Pleomorphic Sarcoma of Bone
  Human Pathology
• gsSKAT: Rapid Gene Set Analysis and Multiple Testing Correction for Rare-variant Association Studies Using Weighted Linear Kernels
  Genetic Epidemiology
• Correlation Between a 2D Channelized Hotelling Observer and Human Observers in a Low-contrast Detection Task with Multi-slice Reading in CT
  Medical Physics Online
• Evaluation of Lactate, White Blood Cell Count, Neutrophil Count, Procalcitonin and Immature Granulocyte Count as Biomarkers for Sepsis in Emergency Department Patients
  Clinical Biochemistry
• Prehospital Blood Transfusions in Pediatric Trauma and Nontrauma Patients: A Single-center Review of Safety and Outcomes
  Pediatric Surgery International

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.