Mayo Clinic Laboratory and Pathology Research Roundup: June 26

By Kelley Luedke • June 26, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Expanded Phenotypes and Outcomes Among 256 LGI1/CASPR2-IgG Positive Patients

Mayo Clinic researchers conducted a study to describe an expanded phenotypic spectrum and longitudinal outcome in 256 LGI1-IgG or CASPR2-IgG seropositive patients. Based on the results, older age is a strong predictor of CNS involvement in patients seropositive for CASPR2-IgG or LGI1-IgG. Pain, peripheral manifestations, and stereotypic "paroxysmal-dizziness-spells" are common with LGI1-IgG. Response to initial immunotherapy is often favorable, but some patients remain severely disabled, requiring long-term immunotherapy and/or antiepileptic medications. The study was published in Annals of Neurology.

Published to PubMed This Week

• Paucicellular Fibrointimal Proliferation Characterizes Pediatric Pulmonary Vein Stenosis: Clinicopathologic Analysis of 213 Samples From 97 Patients
  American Journal of Surgical Pathology
• Validation of a Mitotic Index Cutoff as a Prognostic Marker in Undifferentiated Uterine Sarcomas
  American Journal of Surgical Pathology
  
• Migraine Subclassification via a Data-Driven Automated Approach Using Multimodality Factor Mixture Modeling of Brain Structure Measurements
  Headache
• Clinical Outcomes of HLA-DPB1 Mismatches in 10/10 HLA-Matched Unrelated Donor-Recipient Pairs Undergoing Allogeneic Stem Cell Transplant
  European Journal of Haematology
• Molecular Validation of Chondrogenic Differentiation and Hypoxia Responsiveness of Platelet-Lysate Expanded Adipose Tissue-Derived Human Mesenchymal Stromal Cells
  Cartilage
• Evaluation of Hepatic Fibrosis: A Review From the Society of Abdominal Radiology Disease Focus Panel
  Abdominal Radiology
• Extraskeletal Osteosarcoma: Outcomes and the Role of Chemotherapy
  American Journal of Clinical Oncology
• Management of Refractory Chylous Ascites with Peritoneovenous Shunts
  Journal of Vascular Surgery: Venous and Lymphatic Disorders

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.