Mayo Clinic Laboratory and Pathology Research Roundup: July 3

By Kelley Luedke • July 3, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Comparison of Gadolinium Concentrations within Multiple Rat Organs after Intravenous Administration of Linear versus Macrocyclic Gadolinium Chelates

Mayo Clinic researchers conducted a study to compare gadolinium tissue concentrations of multiple linear and macrocyclic chelates in a rat model to better understand the scope and extent of tissue deposition following multiple intravenous doses of gadolinium-based contrast agent (GBCA). Based on the results, tissue deposition of gadolinium was two- to fourfold higher following administration of the linear agents gadodiamide and gadobenate dimeglumine compared with the macrocyclic agents gadobutrol and gadoteridol. These findings suggest that organ tissue deposition is reduced but not eliminated following administration of macrocyclic GBCA chelates in lieu of linear chelates. The study was published in Radiology.

Published to PubMed This Week

• Glycogen Synthase Kinase-3β Ablation Limits Pancreatitis Induced Acinar-to-Ductal Metaplasia
  Journal of Pathology
• High Rate of Event-Free Survival at 24 Months with Everolimus/RCHOP for Untreated Diffuse Large B-Cell Lymphoma: Updated Results From NCCTG N1085 (Alliance)
  Blood Cancer Journal
  
• Genomic Rearrangements in Sporadic Lymphangioleiomyomatosis: An Evolving Genetic Story
  Modern Pathology
• SMARCA4-Deficient Thoracic Sarcoma: A Distinctive Clinicopathological Entity with Undifferentiated Rhabdoid Morphology and Aggressive Behavior
  Modern Pathology
• Clinical Heterogeneity of Diffuse Large B Cell Lymphoma Following Failure of Front-Line Immunochemotherapy
  British Journal of Haematology
• Prevention of Human Lymphoproliferative Tumor Formation in Ovarian Cancer Patient-Derived Xenografts
  Neoplasia
• Outcome of Surgical Repair of Pulmonary Artery Aneurysms: A Single-Center Experience With 38 Patients
  Annals Thoracic Surgery
• Survival in Surgical and Nonsurgical Patients With Superior Sulcus Tumors
  Annals Thoracic Surgery
• Establishing Human Heart Chromium, Cobalt and Vanadium Concentrations by Inductively Coupled Plasma Mass Spectrometry
  Journal of Trace Elements in Medicine and Biology
• Coffee Consumption and Risk of Renal Cell Carcinoma
  Cancer Causes and Control
• Early Response Index: A Statistic to Discover Potential Early Stage Disease Biomarkers
  BMC Bioinformatics
• Same-Session Bilateral Ureteroscopy: Safety and Outcomes
  Urology
• Primary Renal Paragangliomas and Renal Neoplasia Associated with Pheochromocytoma/Paraganglioma: Analysis of von Hippel-Lindau (VHL), Succinate Dehydrogenase (SDHX) and Transmembrane Protein 127 (TMEM127)
  Endocrine Pathology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.