Mayo Clinic Laboratory and Pathology Research Roundup: Aug. 7

By Kelley Luedke • August 7, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Randomized Controlled Trial of Postoperative Belladonna and Opium Rectal Suppositories in Vaginal Surgery

After vaginal surgery, oral and parenteral narcotics are used commonly for pain relief, and their use may exacerbate the incidence of sedation, nausea, and vomiting, which ultimately delays convalescence. Previous studies have demonstrated that rectal analgesia after surgery results in lower pain scores and less intravenous morphine consumption. Belladonna and opium rectal suppositories may be used to relieve pain and minimize side effects; however, their efficacy has not been confirmed. Mayo Clinic researchers conducted a study aimed to evaluate the use of belladonna and opium suppositories for pain reduction in vaginal surgery. Based on their results, they found belladonna and opium suppositories are safe for use after vaginal surgery. Belladonna and opium suppositories did not reveal lower pain or substantially lower narcotic use. Further investigation may be warranted to identify a population that may benefit optimally from belladonna and opium use. The study was published in the American Journal of Obstetrics & Gynecology.

Published to PubMed This Week

• Akt inhibitor MK-2206 in Combination with Bendamustine and Rituximab in Relapsed or Refractory Chronic Lymphocytic Leukemia: Results From the N1087 Alliance Study
  American Journal of Hematology
• Associations Between Elevated Pre-Treatment Serum Cytokines and Peripheral Blood Cellular Markers of Immunosuppression in Patients with Lymphoma
  American Journal of Hematology
  
• The Utility of MASS-FIX to Detect and Monitor Monoclonal Proteins in the Clinic
  American Journal of Hematology
• Monocytosis in Polycythemia Vera: Clinical and Molecular Correlates
  American Journal of Hematology
• Clinical Decision-Making in Patients with Variant of Uncertain Significance in BRCA1 or BRCA2 Genes
  Annals of Surgical Oncology
• Selective Use of Sentinel Lymph Node Surgery in Patients Undergoing Prophylactic Mastectomy Using Intraoperative Pathology
  Annals of Surgical Oncology
• A Validated Nomogram to Predict Upstaging of Ductal Carcinoma in Situ to Invasive Disease
  Annals of Surgical Oncology
• Temporal Differences in Outcomes during Long-Term Mechanical Circulatory Support
  Journal of Cardiac Failure
• Postlactational Involution Biomarkers Plasminogen and Phospho-STAT3 are Linked with Active Age-Related Lobular Involution
  Breast Cancer Research and Treatment
• Role of Mass Spectrometry in Clinical Endocrinology
  Endocrinology Metabolism Clinics of North America
• Composite Pheochromocytoma/Paraganglioma-Ganglioneuroma: A Clinicopathologic Study of Eight Cases with Analysis of Succinate Dehydrogenase
  Endocrine Pathology
• Measuring and Interpreting Serum AAT Concentration
  Methods in Molecular Biology
• IgLON5 Antibody: Neurological Accompaniments and Outcomes in 20 Patients
  Neurology: Neuroimmunology & Neuroinflammation

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.