Mayo Clinic Laboratory and Pathology Research Roundup: Aug. 28

By Kelley Luedke • August 28, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Review: How I Treat Autoimmune Hemolytic Anemia

Autoimmune hemolytic anemia (AIHA) is an uncommon entity that presents diagnostic, prognostic, and therapeutic dilemmas despite being a well-recognized entity for over 150 years. This is because of significant differences in the rates of hemolysis and associated diseases and because there is considerable clinical heterogeneity. In addition, there is a lack of clinical trials required to refine and update standardized and evidence-based therapeutic approaches. To aid the clinician in AIHA management, Mayo Clinic researchers present four vignettes that represent and highlight distinct clinical presentations with separate diagnostic and therapeutic pathways that are use in their clinical practice setting. The researchers also review the parameters present in diagnostic testing that allow for prognostic insight and present algorithms for both diagnosis and treatment of the AIHA patient in diverse situations. This is done in the hope that this review may offer guidance in regard to personalized therapy recommendations. A section is included for the diagnosis of suspected AIHA with negative test results, a relatively infrequent but challenging situation, in order to assist in the overall evaluation spectrum for these patients. The review was published in Blood.

Published to PubMed This Week

• Application of Current Prognostic Models for Primary Myelofibrosis in the Setting of Post Polycythemia Vera or Post-Essential Thrombocythemia Myelofibrosis
  Leukemia
• Expanded Phenotypes and Outcomes Among 256 LGI1/CASPR2-IgG-Positive Patients
  Annals of Neurology
  
• Outcomes From Bacteremic Donors in Lung Transplantation
  Journal of Heart and Lung Transplantation
• Evaluating the Atherogenic Burden of Individuals with a Friedewald-Estimated Low-Density Lipoprotein Cholesterol <70 mg/dL Compared with a Novel Low-Density Lipoprotein Estimation Method
  Journal of Clinical Lipidology
• BRAF V600E Mutations Occur in a Subset of Glomus Tumors, and are Associated With Malignant Histologic Characteristics
  American Journal of Surgical Pathology
• A Droplet Digital PCR Method for Severe Combined Immunodeficiency Newborn Screening
  Journal of Molecular Diagnostics
• Pulmonary Invasive Mucinous Adenocarcinoma and Mixed Invasive Mucinous/Non-Mucinous Adenocarcinoma- A Clinicopathological and Molecular Genetic Study with Survival Analysis
  Human Pathology
• GAD65 Neurological Autoimmunity
  Muscle Nerve
• Point-of-Care Washing of Allogeneic Red Blood Cells for the Prevention of Transfusion-Related Respiratory Complications (WAR-PRC): A Protocol for a Multicenter Randomised Clinical Trial in Patients Undergoing Cardiac Surgery
  BMJ Open
• Pathology and Diagnosis of Renal Non-AL Amyloidosis
  Journal of Nephrology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.