Mayo Clinic Laboratory and Pathology Research Roundup: Sept. 25

By Kelley Luedke • September 25, 2017

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Rates of Hippocampal Atrophy and Presence of Post-Mortem TDP-43 in Patients with Alzheimer's Disease: A Longitudinal Retrospective Study

Post-mortem studies have not identified an association between β-amyloid or tau and rates of hippocampal atrophy in patients with Alzheimer's disease. TAR DNA binding protein 43 (TDP-43) is another protein linked to Alzheimer's disease. Mayo Clinic researchers aimed to investigate whether hippocampal TDP-43 is associated with increased rates of hippocampal atrophy. In this longitudinal retrospective study, researchers analyzed post-mortem brain tissue of all individuals with an Alzheimer's disease spectrum pathological diagnosis who had antemortem head MRI scans between Jan 1, 1999, and Dec 31, 2012. Based on the results, TDP-43 should be considered as a potential factor related to increased rates of hippocampal atrophy in patients with Alzheimer's disease. Given the importance of hippocampal atrophy in Alzheimer's disease, it is imperative that techniques are developed for detection of TDP-43 in vivo. The review was published in The Lancet. Neurology.

Published to PubMed This Week

• Postoperative Stereotactic Radiosurgery Compared with Whole Brain Radiotherapy for Resected Metastatic Brain Disease (NCCTG N107C/CEC·3): A Multicentre, Randomised, Controlled, Phase 3 Trial
  Lancet Oncology
• Exuberant Nodal Proliferation of Mature Plasmacytoid Dendritic Cells in a Patient with Chronic Myelomonocytic Leukemia
  Blood
  
• Risk of Histological Transformation and Therapy-Related Myelodysplasia/Acute Myeloid Luekaemia in Patients Receiving Radioimmunotherapy for Follicular Lymphoma
  British Journal of Haematology
• Prognostic Value of Soluble ST2 After Myocardial Infarction: A Community Perspective
  American Journal of Medicine
• Fatty Acid Synthase (FASN) as a Therapeutic Target in Breast Cancer
  Expert Opinion on Therapeutic Targets
• Trends of Inguinal Hernia Repairs Performed for Recurrence in the United States
  Surgery
• Impact of Histopathology, Tumor-Infiltrating Lymphocytes, and Adjuvant Chemotherapy on Prognosis of Triple-Negative Breast Cancer
  Breast Cancer Research and Treatment
• Prehospital Plasma Resuscitation Associated with Improved Neurologic Outcomes After Traumatic Brain Injury
  Journal of Trauma and Acute Care Surgery
• Sex-Specific 99th Percentiles Derived from the AACC Universal Sample Bank for the Roche Gen 5 cTnT Assay: Comorbidities and Statistical Methods Influence Derivation of Reference Limits
  Clinical Biochemistry

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.