Mayo Clinic Laboratory and Pathology Research Roundup: Oct. 2

By Kelley Luedke • October 2, 2017

Share this:

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Immune-Mediated Autonomic Neuropathies following Allogeneic Stem Cell Transplantation in Acute Myeloid Leukemia

Autonomic dysfunction (AD) after allogeneic stem cell transplant (SCT) is a rare occurrence and likely immune-mediated in etiology. There is limited literature on this topic and Mayo Clinic researchers describe management of two cases at the institution and their outcomes. They retrospectively identified two patients with immune-mediated AD after SCT from their database. Immune-mediated AD was defined as AD secondary to an immune-mediated etiology without an alternative cause and responding to immunosuppression. Based on the results, AD after SCT is a rare yet significant clinical entity. A workup of underlying etiology should be performed. IVIG is a treatment option for these patients. The review was published in Case Reports in Hematology.

Published to PubMed This Week

• Pembrolizumab-Induced Thyroiditis: Comprehensive Clinical Review and Insights Into Underlying Involved Mechanisms
  Journal of Clinical Endocrinology & Metabolism
• Roles of Kallikrein-2 Biomarkers (free-hK2 and pro-hK2) for Predicting Prostate Cancer Progression-Free Survival
  Journal of Circulating Biomarkers
• Liver Dysfunction in Chronic Lymphocytic Leukemia: Prevalence, Outcomes, and Pathological Findings
  American Journal of Hematology
• Paired Comparison of Therapeutic Plasma Exchange Using the Fenwal Amicus Versus TerumoBCT Spectra Optia
  Journal of Clinical Apheresis
• Percutaneous Transcatheter Biopsy for Intracardiac Mass Diagnosis
  EuroIntervention
• Giant Cell Ependymoma of the Lateral Ventricle: Case Report, Literature Review, and Analysis of Prognostic Factors and Genetic Profile
  World Neurosurgery
• Isolated Polyarteritis Nodosa Presenting as Bilateral Testicular Swelling
  American Journal of Medicine
• Update on Immunohistochemical Analysis in Breast Lesions
  Archives of Pathology & Laboratory Medicine
• Revisiting Adjuvant Radiotherapy After Gross Total Resection of World Health Organization Grade II Meningioma
  World Neurosurgery
• Soluble ST2 Does Not Change Cardiovascular Risk Prediction Compared to Cardiac Troponin T in Kidney Transplant Candidates
  PLoS One
• TCR-CXCR4 Signaling Stabilizes Cytokine mRNA Transcripts via a PREX1-Rac1 Pathway: Implications for CTCL
  Blood
• Giant Cell Ependymoma of the Lateral Ventricle: Case Report, Literature Review, and Analysis of Prognostic Factors and Genetic Profile
  World Neurosurgery
• Rapid kV-Switching Single-Source Dual-Energy CT ex Vivo Renal Calculi Characterization Using a Multiparametric Approach: Refining Parameters on an Expanded Dataset
  Abdominal Radiology
• Low Hypoxia Inducible Factor-1α (HIF-1α) Expression in Testicular Germ Cell Tumors - A Major Reason for Enhanced Chemosensitivity
  Chinese Journal of Cancer Research
• Glycogen Synthase Kinase-3β Ablation Limits Pancreatitis-Induced Acinar-to-Ductal Metaplasia
  Journal of Pathology
• Diagnostic Utility of IDH1/2 Mutations to Distinguish Dedifferentiated Chondrosarcoma From Undifferentiated Pleomorphic Sarcoma of Bone
  Human Pathology
• Interphase Fluorescence in situ Hybridization in Untreated AL Amyloidosis Has an Independent Prognostic Impact by Abnormality Type and Treatment Category
  Leukemia
• Comprehensive Immune Profiling Reveals Substantial Immune System Alterations in a Subset of Patients with Amyotrophic Lateral Sclerosis
  PLoS One

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.